Oseltamivir susceptibility in south-western France during the 2007-8 and 2008-9 influenza epidemics and the ongoing influenza pandemic 2009

Abstract

The recent emergence of seasonal influenza A(H1N1) strains resistant to oseltamivir makes it necessary to monitoring carefully the susceptibility of human influenza viruses to neuraminidase inhibitors. We report the prevalence of the oseltamivir resistance among influenza A viruses circulating in south-western France over the past three years: seasonal influenza A(H1N1), seasonal influenza A(H3N2), and the influenza A(H1N1)v viruses associated with the ongoing 2009 pandemic. The main result of the study is the absence of oseltamivir resistance in the pandemic H1N1 strains studied so far (n=129).

Pandemic influenza A(H1N1)2009: molecular characterisation and duration of viral shedding in intensive care patients in Bordeaux, south-west France, May 2009 to January 2010

“…The H275Y (N1 numbering) mutation conferring resistance to oseltamivir was investigated on admission on the first specimen by a fluorescence resonance energy transfer (FRET)-based assay designed in the virology laboratory in Bordeaux as previously described [6].…”

Detection of Oseltamivir-Resistant Influenza A (H1N1) Viruses with H274Y Mutation during the 2007 - 2008 Influenza Season in Turkey

“…These were associated with a specific "histidine-totyrosine mutation" at position 274 (H274Y; H275Y in N1 numbering system) in the neurominidase (NA) protein that confers high-level resistance to oseltamivir (1)(2)(3)(4)(5)). An increased number of influenza A viruses (H1N1) with resistance to oseltamivir was first reported by recent reports showed that most influenza A (H1N1) virus strains were resistant to oseltamivir (1)(2)(3)(4)(5)(6)(7)(8)11).…”