Oseltamivir for prophylaxis of influenza in vaccinated hemodialysis patients

Abstract

manufacturer's instructions (Table 1). Our results show an antibiotic resistance profile similar to those previously observed in Canada with their local M. saskatchewanense strains. 6 Some differences were also noted; for example, the MIC for rifampicin for all Canadian strains is 0.06 μg/mL, whereas our strain displayed a value of 8 μg/mL for the same antibiotic (Table 1). Although we cannot exclude the possibility that the differences observed may be due to the use of different assays, they may also indicate that the Italian M. saskatchewanense has either undergone mutations since it left North America or that its origin lies elsewhere. However, no epidemiological data about this NTM are currently available, and we can only speculate about whether it derives from the North American strains or from some other geographical location. To the best of our knowledge, we report for the first time the detection of a M. saskatchewanense clinical isolate in a European health facility. Our results highlight the fact that screening assays for TB detection in blood can produce misleading results and could lead to incorrect antimicrobial therapy. Careful evaluation for mycobacterial infection must be performed, and the organism must be identified and coupled with highly discriminating techniques such as NGS, as necessary.