Oseltamivir: A First Line Defense Against Swine Flu

Agrawal, Ritesh; Rewatkar, Prarthana; Kokil, Ganesh R.; Verma, Ankita; Kalra, Atin

doi:10.2174/1573406411006040247

Cited by 18 publications

(13 citation statements)

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“…Anti-viral drugs such as oseltamivir (brand name Tamiflu©) and zanamivir (brand name Relenza©) were recommended as effective treatment options [6,7] . Supplies of the 2009 H1N1 vaccine were limited in many countries.…”

mentioning

confidence: 99%

Nursing students’ experiences of exposure to pandemic influenza A (H1N1)

Kang

2012

JNEP

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Background:The purpose of this study was to examine the experiences of nursing students with exposure of influenza A (H1N1). Methods:A qualitative descriptive study design was used. A total of 24 nursing students participated in six focus groups. Results:The six themes that emerged from the data are as follows: (1) worrying about becoming infected; (2) protecting oneself and others; (3) relying on the nurses in the school health center; (4) being hurt by others' negative reactions; (5) being ambivalent, and (6) being concerned over the high price. Conclusion:Nursing students who come in contact with patients in a clinical setting must also be considered as candidates for early vaccination. Healthcare professionals, as well as family and friends, should keep in mind that their verbal or nonverbal expressions can hurt others' feelings at a time when special care and support are needed the most. Stigma could be serious barriers of people's access to health services and preventive behaviors. Therefore, education on stigma reduction associated with pandemic infection is essential to enhance public health preparedness.

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confidence: 99%

Nursing students’ experiences of exposure to pandemic influenza A (H1N1)

Kang

2012

JNEP

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“…According to studies, LNT can reduce inflammatory damage by reducing inflammatory cytokine release and can also control inflammation by inhibiting the TLR4 signaling pathway, thereby acting as an antiviral ( Nishitani et al., 2013 ; Liu et al., 2019 ; Murphy et al., 2020 ). Based on these results, we speculate that LNT can treat influenza A. Oseltamivir is widely used as a neuraminidase inhibitor in the treatment of influenza A ( Agrawal et al., 2010 ). Many studies on anti-influenza effects and mechanisms of drugs chose the ICR mouse model ( Geng et al., 2019 ; Du et al., 2020 ; Yu et al., 2020 ; Cui et al., 2022 ).…”

Section: Introductionmentioning

confidence: 79%

Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model

Zhang

Zhang²,

Cai³

et al. 2022

Front. Cell. Infect. Microbiol.

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Influenza virus is a serious threat to global human health and public health security. There is an urgent need to develop new anti-influenza drugs. Lentinan (LNT) has attracted increasing attention in recent years. As potential protective agent, LNT has been shown to have anti-tumor, anti-inflammatory, and antiviral properties. However, there has been no further research into the anti-influenza action of lentinan in vivo, and the mechanism is still not fully understood. In this study, the anti-influenza effect and mechanism of Lentinan were studied in the Institute of Cancer Research (ICR) mouse model. The results showed that Lentinan had a high degree of protection in mice against infection with influenza A virus, delayed the emergence of clinical manifestations, improved the survival rate of mice, significantly prolonged the middle survival days, attenuated the weight loss, and reduced the lung coefficient of mice. It alleviated the pathological damage of mice infected with the influenza virus and improved blood indices. Lentinan treatment considerably inhibited inflammatory cytokine (TNF-α, IL-1β, IL-4, IL-5, IL-6) levels in the serum and lung and improved IFN-γ cytokine levels, which reduced cytokine storms caused by influenza virus infection. The underlying mechanisms of action involved Lentinan inhibiting the inflammatory response by regulating the TLR4/MyD88 signaling pathway. This study provides a foundation for the clinical application of Lentinan, and provides new insight into the development of novel immunomodulators.

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“…It acts by competitive inhibition of neuraminidase enzyme which ultimately prevents the release of new virions (Lew et al, 2012). It is a prodrug and has to undergo ester hydrolysis to Oseltamivir carboxylate which is the active form (Agrawal et al, 2010).…”

Section: Oseltamivirmentioning

confidence: 99%

A review of the structure-activity relationships (SAR) of selected drugs with potential to be repurposed against SARS-COV-2

Ajima¹,

Kolawole²,

Falang³

et al. 2021

Asian J Pharm Pharmacol

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Background: The pandemic caused by the novel SARS-CoV-2 virus has escalated rapidly and impacted human health worldwide, in addition to causing severe disruptions to socioeconomic life. There is presently no effective treatment for the disease and this underscores the urgent need for new therapeutic options against this life threatening disease. The traditional strategy for the development of new drugs is a slow and expensive process. Drug repurposing is a valuable alternative strategy that can be used to bypass some of the limitations of traditional drug discovery in order to rapidly develop new therapeutic agents for the management of Covid-19.The present review x-rays recent efforts to re-purpose some antiviral drugs for the treatment Objectives: of SARS-Cov-2 with an emphasis on the structure activity relationships (SAR) of the compounds.A systematic internet Methods: search of three academic databases of published literature was undertaken using relevant keywords and search terms which focused on drug re-purposing against SARS-CoV-2.A total of 853 results were generated and evaluated. The results of the search Results: were screened and relevant articles identified, yielding a total of 83 articles. Some of the drugs identified with potential for repurposing against SARS-CoV-2 include: Arbidol, Favipiravir, Ribavirin, Nitazoxanide etc.It is hoped that the Conclusion: information generated in this review will help deepen understanding of the potential mechanism of anti-SARS-CoV-2 action of the compounds and also draw attention to opportunities that exist for structural modification of these molecules with the aim of improving and enhancing their selectivity and efficacy against SARS-CoV-2.

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Oseltamivir: A First Line Defense Against Swine Flu

Cited by 18 publications

References 0 publications

Nursing students’ experiences of exposure to pandemic influenza A (H1N1)

Nursing students’ experiences of exposure to pandemic influenza A (H1N1)

Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model

A review of the structure-activity relationships (SAR) of selected drugs with potential to be repurposed against SARS-COV-2

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