Oscillatory work and the step that generates force in single myofibrils from rabbit psoas
Masataka Kawai,
Bogdan Iorga
Abstract:The elementary molecular step that generates force by cross-bridges (CBs) in an active muscle has been under intense investigation in the field of muscle biophysics. The question asked here is whether this step is before phosphate (Pi) release or after its release. It is known that an increase in the concentration of Pi ([Pi]) diminishes isometric force in Ca 2+ activated fibers, indicating a tight coupling between the force-generating step and the Pi release step. We investigated the effect of Pi on oscillato… Show more
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