Oscillatory Patterns in Sympathetic Neural Discharge and Cardiovascular Variables During Orthostatic Stimulus

Furlan, Raffaello; Porta, Alberto; Costa, Fernando; Tank, Jens; Baker, Lemont; Schiavi, Richard; Robertson, David L.; Malliani, Alberto; Mosqueda‐Garcia, Rogelio

doi:10.1161/01.cir.101.8.886

Cited by 313 publications

(319 citation statements)

References 32 publications

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“…Therefore, future trials designed to test the ability of respiratory-gated symbolic analysis should account for the previous observation to compute the sample size. The smallness of the sample size of this study was emphasized also by the inability to detect the decrease of the HP variance and the increase of the SAP variance during TILT [31][32][33]35]. The non-significant trends observed in this study during TILT might turn into significant differences if the sample size was augmented.…”

Section: Discussionmentioning

confidence: 69%

“…This finding suggested that coupling between fast features of MSNA and SAP series, quantified by 2UV-2UV%, plays a significant role in the MSNA-SAP coordination. Remarkably, orthostatic challenge significantly reduced 2UV-2UV%, thus suggesting that sympathetic overactivity and/or the increase of sympathetic modulation was able to reduce this type of coordinated MSNA-SAP behaviour probably by augmenting the importance of slower rhythms [32].…”

Section: Discussionmentioning

confidence: 91%

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Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans

Porta

Marchi²,

Bari

et al. 2015

Phil. Trans. R. Soc. A.

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We propose a symbolic analysis framework for the quantitative characterization of complex dynamical systems. It allows the description of the time course of a single variable, the assessment of joint interactions and an analysis triggered by a conditioning input. The framework was applied to spontaneous variability of heart period (HP), systolic arterial pressure (SAP) and integrated muscle sympathetic nerve activity (MSNA) with the aim of characterizing cardiovascular control and nonlinear influences of respiration at rest in supine position, during orthostatic challenge induced by 80° head-up tilt (TILT) and about 3 min before evoked pre-syncope signs (PRESY). The approach detected (i) the exaggerated sympathetic modulation and vagal withdrawal from HP variability and the increased presence of fast MSNA variability components during PRESY compared with TILT; (ii) the increase of the SAP–HP coordination occurring at slow temporal scales and a decrease of that occurring at faster time scales during PRESY compared with TILT; (iii) the reduction of the coordination between fast MSNA and SAP patterns during TILT and PRESY; (iv) the nonlinear influences of respiration leading to an increased likelihood to observe the abovementioned findings during expiration compared with inspiration one. The framework provided simple, quantitative indexes able to distinguish experimental conditions characterized by different states of the autonomic nervous system and to detect the early signs of a life threatening situation such as postural syncope.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 91%

Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans

Porta

Marchi²,

Bari

et al. 2015

Phil. Trans. R. Soc. A.

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“…Low-frequency blood pressure oscillations, the so-called Mayer waves, are mediated by the sympathetic nervous system. 24,25 Similarly, selective norepinephrine transporter blockade with reboxetine attenuates low-frequency systolic blood pressure oscillations. 12 Moreover, we observed a marked reduction in venous plasma norepinephrine concentration with sibutramine.…”

Section: Discussionmentioning

confidence: 99%

Paradoxical Effect of Sibutramine on Autonomic Cardiovascular Regulation

et al. 2002

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Background-Sibutramine, a serotonin and norepinephrine transporter blocker, is widely used as an adjunctive obesity treatment. Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease. Methods and Results-In 11 healthy subjects (7 men, age 27Ϯ2 years, body mass index 23.1Ϯ0.7 kg/m 2 ), we compared the effect of sibutramine or matching placebo (ingested 26, 14, and 2 hours before testing) on cardiovascular responses to autonomic reflex tests and to a graded head-up tilt test. In addition, we tested sibutramine in combination with metoprolol. Testing was conducted in a double-blind and crossover fashion. Supine systolic blood pressure was 113Ϯ3 mm Hg with placebo, 121Ϯ3 mm Hg with sibutramine (PϽ0.001 versus placebo), and 111Ϯ2 mm Hg with the combination of sibutramine and metoprolol. Similarly, sibutramine increased upright blood pressure. Sibutramine substantially increased upright heart rate. This effect was abolished with metoprolol. The blood pressure response to cold pressor and handgrip testing was attenuated with sibutramine compared with placebo. Furthermore, sibutramine decreased low-frequency oscillations of blood pressure and plasma norepinephrine concentrations in the supine position. Conclusions-The cardiovascular effect of the antiobesity drug sibutramine results from a complex interaction of peripheral and central nervous system effects. The inhibitory clonidine-like action of sibutramine on the central nervous system attenuates the peripheral stimulatory effect. Our findings strongly suggest that current concepts regarding the action of sibutramine on the sympathetic nervous system should be reconsidered.

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“…Although some studies have implied that the LF component of HRV as well as the LF/HF ratio might reflect the parasympathetic cardiac modulation or the baroreflex 13,28 , the LF component has usually been associated with sympathetic activity 29,30 . In the present study, there was an increase in the LF/HF component of HRV in the infarcted animals.…”

Section: (5) 2016 -343mentioning

confidence: 99%

Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

Pasqualin

Mostarda²,

Souza³

et al. 2016

Acta Cir. Bras.

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PURPOSE:To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS:Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated. RESULTS:The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS. CONCLUSION:Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in postacute myocardial infarction period.Key words: Autonomic Nervous System. Heart Rate. Myocardial Infarction. Ischemic Preconditioning, Myocardial. Rats. Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

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Oscillatory Patterns in Sympathetic Neural Discharge and Cardiovascular Variables During Orthostatic Stimulus

Abstract: During the sympathetic activation induced by tilt, a similar oscillatory pattern based on an increased LF rhythmicity characterized the spontaneous variability of neural sympathetic discharge, R-R interval, and arterial pressure.

Cited by 313 publications

References 32 publications

Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans

Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans

Paradoxical Effect of Sibutramine on Autonomic Cardiovascular Regulation

Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

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