Oscillatory MEG response to human locomotion is modulated by periventricular lesions

Pavlova, Marina; Lutzenberger, Werner; Sokolov, Alexander N.; Birbaumer, Niels; Krägeloh‐Mann, Ingeborg

doi:10.1016/j.neuroimage.2007.01.030

Cited by 26 publications

(13 citation statements)

References 58 publications

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“…In controls, there was no difference in RMS amplitude between walker-present and mask-only displays. In earlier work, we did show that oscillatory MEG response to camouflaged human locomotion (26.5 Hz) peaked at a latency of 170 msec over the right parieto-temporal cortex, whereas enhancement in PVL patients occurred later, at a latency of 290 msec over the left temporal cortex (Pavlova, Lutzenberger, et al, 2007). We explained this delayed latency of the evoked oscillatory MEG response by alterations in association fibers, which are longer, thinner, and less numerous in PVL patients (Skranes et al, 2007;Thomas et al, 2005;Hoon et al, 2002).…”

Section: Discussionmentioning

confidence: 58%

“…Although performance IQ scores of PVL patients were lower, there was no significant difference between the groups. The impairments of PVL patients on performance IQ based on visual-perceptual and attentional tasks, and the relationship of these difficulties to visual processing of body motion are reported earlier (Pavlova, Sokolov, Birbaumer, & Krägeloh-Mann, 2008;Pavlova, Lutzenberger, Sokolov, Birbaumer, & Krägeloh-Mann, 2007;Pavlova et al, 2005). The outcome of these studies indicates that deficiencies in the visual processing of body motion and in performance on the visual-perceptual tasks constituting performance IQ measured by HAWIK-III are associated with the severity and distinct topography of PVL.…”

Section: Participantsmentioning

confidence: 72%

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Neuromagnetic Response to Body Motion and Brain Connectivity

Pavlova

Bidet-Ildei

Sokolov

et al. 2009

Journal of Cognitive Neuroscience

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Visual detection of body motion is of immense importance for daily-life activities and social nonverbal interaction. Although neurobiological mechanisms underlying visual processing of human locomotion are being explored extensively by brain imaging, the role of structural brain connectivity is not well understood. Here we investigate cortical evoked neuromagnetic response to point-light body motion in healthy adolescents and in patients with early periventricular lesions, periventricular leukomalacia (PVL), that disrupt brain connectivity. In a simultaneous masking paradigm, participants detected the presence of a point-light walker embedded in a few sets of spatially scrambled dots on the joints of a walker. The visual sensitivity to camouflaged human locomotion was lower in PVL patients. In accord with behavioral data, root-mean-square (RMS) amplitude of neuromagnetic trace in response to human locomotion was lower in PVL patients at latencies of 180-244 msec over the right temporal cortex. In this time window, the visual sensitivity to body motion in controls, but not in PVL patients, was inversely linked to the right temporal activation. At later latencies of 276-340 msec, we found reduction in RMS amplitude in PVL patients for body motion stimuli over the right frontal cortex. The findings indicate that disturbances in brain connectivity with the right temporal cortex, a key node of the social brain, and with the right frontal cortex lead to disintegration of the neural network engaged in visual processing of body motion. We suspect that reduced cortical response to body motion over the right temporal and frontal cortices might underlie deficits in visual social cognition.

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Section: Discussionmentioning

confidence: 58%

Section: Participantsmentioning

confidence: 72%

Neuromagnetic Response to Body Motion and Brain Connectivity

Pavlova

Bidet-Ildei

Sokolov

et al. 2009

Journal of Cognitive Neuroscience

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“…Even though this profile can be observed in 3‐year‐olds, the difference becomes more pronounced as children enter school . PVL affects the brain connectivity in the temporal–parietal cortex, is particularly frequent in children born preterm, and leads to visual–perceptual impairments …”

Section: Resultsmentioning

confidence: 98%

Cognitive functioning in children with cerebral palsy

Stadskleiv

2020

Develop Med Child Neuro

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PVL Periventricular leukomalaciaChildren with cerebral palsy (CP) have an increased risk of cognitive impairments. This narrative review of the literature discusses assessment of cognition in children with CP, presents the most salient characteristics of cognitive functioning pertaining to each subtype, and discusses the relationships between brain injury, functioning, and intervention from a developmental perspective. A search for original studies of cognitive functioning in children with different subtypes of CP was performed. The search resulted in 81 unique hits. There were few studies with a representative sample of children with CP where all participants were individually assessed. Cognitive functioning in children with the most severe motor impairments were often assumed and not assessed. Furthermore, there was a confounding of IQ below 70 and intellectual disability, possibly leading to an overestimation of the prevalence of intellectual disability. Longitudinal neuropsychological studies, including also very young children and those with the most severe speech and motor impairments, as well as intervention studies, are called for.

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“…The modulation of the MEG response is, therefore, stimulus-specific and topographically distinct. Moreover, even mild periventricular lesions modulate the proper functioning of the cortical neuronal assemblies tuned to biological motion by altering their synchronous oscillatory activity over the right temporal lobe (Pavlova, Lutzenberger, Sokolov, Birbaumer, & Krägeloh-Mann, 2007).…”

Section: Introductionmentioning

confidence: 99%

Perception and Understanding of Others' Actions and Brain Connectivity

Pavlova

Sokolov

Birbaumer

et al. 2008

Journal of Cognitive Neuroscience

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Perception and Understanding of dispositions and intentions of others through their actions are of immense importance for adaptive daily-life behavior and social communication. Here we ask whether, and, if so, how this ability is impaired in adolescents who were born premature and suffer early periven-tricular damage, periventricular leukomalada (PVL) that affects brain Connectivity. The visual event arrangement (EA) task was administered to PVL patients and two control groups, premature-born and term-born adolescents without brain abnormalities on a magnetic resonance imaging scan. Performance on the EA task was significantly lower in PVL patients as compared with controls. No difference was found between premature-born participants without lesions and term-born controls. Performance on the EA task was inversely related to the Volumetrie extent of lesions in the parieto-occipital regions of both hemispheres and, in particular, to the right temporal periventricular lesions. Whereas our earlier work reveals that compromised visual processing of biological motion, impairments in visual navigation, and other visual-perceptual disabilities in PVL patients are associated with parieto-ocdpital lesions, difflculties in the visual EA task solefy are speciflcally linked to the right temporal periventricular lesions. For the ftrst time, we show that the severity of the right temporal PVL can serve äs a predictor of the ability for perception and understanding of others' actions. We assume that impairments in this ability in PVL patients are caused by disrupted brain Connectivity to the right temporal cortex, a key node of the social brain.

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Oscillatory MEG response to human locomotion is modulated by periventricular lesions

Cited by 26 publications

References 58 publications

Neuromagnetic Response to Body Motion and Brain Connectivity

Neuromagnetic Response to Body Motion and Brain Connectivity

Cognitive functioning in children with cerebral palsy

Perception and Understanding of Others' Actions and Brain Connectivity

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