Oscillatory differentiation dynamics fundamentally restricts the resolution of pseudotime reconstruction algorithms
Huy K. Vo,
Jonathan H. P. Dawes,
Robert N. Kelsh
Abstract:The challenge to understand differentiation and cell lineages in development has resulted in many bioinformatics software tools, notably those working with gene expression data obtained via single-cell RNA sequencing obtained at snapshots in time. Reconstruction methods for trajectories often proceed by dimension reduction, data clustering and then computation of a tree graph in which edges indicate closely related clusters. Cell lineages can then be deduced by following paths through the tree. In the case of … Show more
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