Oscillatoria limnetica Mediated Green Synthesis of Iron Oxide (Fe2O3) Nanoparticles and Their Diverse In Vitro Bioactivities

Haris, Muhammad Salahuddin; Fatima, Namra; Iqbal, Javed; Chalgham, Wadie; Mumtaz, Abdul Samad; El‐Sheikh, Mohamed A.; Tavafoghi, Maryam

doi:10.3390/molecules28052091

Cited by 21 publications

(9 citation statements)

References 59 publications

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“…Hassan et al (2022) produced green-synthesized FeO NPs with an average diameter of 31.45 nm, which were observed using SEM to illustrate the dimensions and morphology of the mostly spherical NPs [111]. Haris et al (2023) investigated the geometry of biosynthesized FeO NPs using SEM and confirmed the presence of trigonal rhombohedral crystalline forms, which is consistent with the XRD findings. The formation of distinct shapes in large particles can be attributed to the crystal development process.…”

Section: Scanning Electron Microscopy (Sem)-energy Dispersive X-ray S...supporting

confidence: 53%

“…The examination conducted using EDX analysis provided qualitative and quantitative information regarding the presence and concentration of Fe components involved in the production of FeONP. Absorption peaks were observed in the energy range of 6-7 keV as a result of the surface plasmon resonance exhibited by Fe NPs [119].…”

Section: Scanning Electron Microscopy (Sem)-energy Dispersive X-ray S...mentioning

confidence: 99%

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Advances in the Optimization of Fe Nanoparticles: Unlocking Antifungal Properties for Biomedical Applications

Sandhu,

Raza,

Alqurashi

et al. 2024

Pharmaceutics

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In recent years, nanotechnology has achieved a remarkable status in shaping the future of biological applications, especially in combating fungal diseases. Owing to excellence in nanotechnology, iron nanoparticles (Fe NPs) have gained enormous attention in recent years. In this review, we have provided a comprehensive overview of Fe NPs covering key synthesis approaches and underlying working principles, the factors that influence their properties, essential characterization techniques, and the optimization of their antifungal potential. In addition, the diverse kinds of Fe NP delivery platforms that command highly effective release, with fewer toxic effects on patients, are of great significance in the medical field. The issues of biocompatibility, toxicity profiles, and applications of optimized Fe NPs in the field of biomedicine have also been described because these are the most significant factors determining their inclusion in clinical use. Besides this, the difficulties and regulations that exist in the transition from laboratory to experimental clinical studies (toxicity, specific standards, and safety concerns) of Fe NPs-based antifungal agents have been also summarized.

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Section: Scanning Electron Microscopy (Sem)-energy Dispersive X-ray S...supporting

confidence: 53%

Section: Scanning Electron Microscopy (Sem)-energy Dispersive X-ray S...mentioning

confidence: 99%

Advances in the Optimization of Fe Nanoparticles: Unlocking Antifungal Properties for Biomedical Applications

Sandhu,

Raza,

Alqurashi

et al. 2024

Pharmaceutics

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“…Another study reported the successful synthesis of Fe 2 O 3 -NPs from Oscillatoria limnetica . Researchers reported significant antibacterial activities of Fe 2 O 3 -NPs against MDR E. coli , S. aureus , and B. subtilis [ 24 ]. Likewise, Fe 2 O 3 -NPs were produced effectively by utilizing gum extract from Bombax malabaricum .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Biological Properties of Iron Oxide Nanoparticles Synthesized from Apis mellifera Honey

Shahid,

Shah,

Shah Bukhari

et al. 2023

Molecules

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Green approaches for nanoparticle synthesis have emerged as biocompatible, economical, and environment-friendly alternatives to counteract the menace of microbial drug resistance. Recently, the utilization of honey as a green source to synthesize Fe2O3-NPs has been introduced, but its antibacterial activity against one of the opportunistic MDR pathogens, Klebsiella pneumoniae, has not been explored. Therefore, this study employed Apis mellifera honey as a reducing and capping agent for the synthesis of iron oxide nanoparticles (Fe2O3-NPs). Subsequent to the characterization of nanoparticles, their antibacterial, antioxidant, and anti-inflammatory properties were appraised. In UV-Vis spectroscopic analysis, the absorption band ascribed to the SPR peak was observed at 350 nm. XRD analysis confirmed the crystalline nature of Fe2O3-NPs, and the crystal size was deduced to be 36.2 nm. Elemental analysis by EDX validated the presence of iron coupled with oxygen in the nanoparticle composition. In ICP-MS, the highest concentration was of iron (87.15 ppm), followed by sodium (1.49 ppm) and other trace elements (<1 ppm). VSM analysis revealed weak magnetic properties of Fe2O3-NPs. Morphological properties of Fe2O3-NPs revealed by SEM demonstrated that their average size range was 100–150 nm with a non-uniform spherical shape. The antibacterial activity of Fe2O3-NPs was ascertained against 30 clinical isolates of Klebsiella pneumoniae, with the largest inhibition zone recorded being 10 mm. The MIC value for Fe2O3-NPs was 30 µg/mL. However, when mingled with three selected antibiotics, Fe2O3-NPs did not affect any antibacterial activity. Momentous antioxidant (IC50 = 22 µg/mL) and anti-inflammatory (IC50 = 70 µg/mL) activities of Fe2O3-NPs were discerned in comparison with the standard at various concentrations. Consequently, honey-mediated Fe2O3-NP synthesis may serve as a substitute for orthodox antimicrobial drugs and may be explored for prospective biomedical applications.

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“…For instance, cyanobacteria Leptolyngbya valderiana [ 29 ], Leptolyngbya sp. WUC 59 [ 30 ], Nostoc ellipsosporum [ 31 ], Anabaena flos-aquae and Calothrix pulvinata [ 32 ] Oscillatoria limnetica [ 33 ] were employed for the biogenic synthesis of FeONPs. Oscillatoria limnetica and Desertifilum sp.…”

Section: Introductionmentioning

confidence: 99%

Biogenic Fabrication of Iron Oxide Nanoparticles from Leptolyngbya sp. L-2 and Multiple In Vitro Pharmacogenetic Properties

Minhas,

Kaleem,

Minhas

et al. 2023

Toxics

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Metallic nanoparticles have received a significant amount of reflection over a period of time, attributed to their electronic, specific surface area, and surface atom properties. The biogenic synthesis of iron oxide nanoparticles (FeONPs) is demonstrated in this study. The green synthesis of metallic nanoparticles (NPs) is acquiring considerable attention due to its environmental and economic superiorities over other methods. Leptolyngbya sp. L-2 extract was employed as a reducing agent, and iron chloride hexahydrate (FeCl3·6H2O) was used as a substrate for the biogenic synthesis of FeONPs. Different spectral methods were used for the characterization of the biosynthesized FeONPs, ultraviolet-visible (UV-Vis) spectroscopy gave a surface plasmon resonance (SPR) peak of FeONPs at 300 nm; Fourier transform infrared (FTIR) spectral analysis was conducted to identify the functional groups responsible for both the stability and synthesis of FeONPs. The morphology of the FeONPs was investigated using scanning electron microscopy (SEM), which shows a nearly spherical shape, and an X-ray diffraction (XRD) study demonstrated their crystalline nature with a calculated crystallinity size of 23 nm. The zeta potential (ZP) and dynamic light scattering (DLS) measurements of FeONPs revealed values of −8.50 mV, suggesting appropriate physical stability. Comprehensive in-vitro pharmacogenetic properties revealed that FeONPs have significant therapeutic potential. FeONPs have been reported to have potential antibacterial and antifungal properties. Dose-dependent cytotoxic activity was shown against Leishmania tropica promastigotes (IC50: 10.73 µg/mL) and amastigotes (IC50: 16.98 µg/mL) using various concentrations of FeONPs. The cytotoxic potential was also investigated using brine shrimps, and their IC50 value was determined to be 34.19 µg/mL. FeONPs showed significant antioxidant results (DPPH: 54.7%, TRP: 49.2%, TAC: 44.5%), protein kinase (IC50: 96.23 µg/mL), and alpha amylase (IC50: 3745 µg/mL). The biosafety of FeONPs was validated by biocompatibility tests using macrophages (IC50: 918.1 µg/mL) and red blood cells (IC50: 2921 µg/mL). In conclusion, biogenic FeONPs have shown potential biomedical properties and should be the focus of more studies to increase their nano-pharmacological significance for biological applications.

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Oscillatoria limnetica Mediated Green Synthesis of Iron Oxide (Fe2O3) Nanoparticles and Their Diverse In Vitro Bioactivities

Cited by 21 publications

References 59 publications

Advances in the Optimization of Fe Nanoparticles: Unlocking Antifungal Properties for Biomedical Applications

Advances in the Optimization of Fe Nanoparticles: Unlocking Antifungal Properties for Biomedical Applications

Synthesis, Characterization, and Biological Properties of Iron Oxide Nanoparticles Synthesized from Apis mellifera Honey

Biogenic Fabrication of Iron Oxide Nanoparticles from Leptolyngbya sp. L-2 and Multiple In Vitro Pharmacogenetic Properties

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