Oscillator Motif as Design Pattern for the Spinal Cord Circuitry Reconstruction

Talanov, Max; Leukhin, Alexey; Suleimanova, Alina; Toschev, Alexander; Lavrov, Igor

doi:10.1007/s12668-020-00743-z

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…More than that, attempts to compensate for spastic syndrome have led to the development of several devices (Palmcrantz et al, 2020;Pennati et al, 2021). In this study, we used the previously proposed approach for the neurointerface (Talanov et al, 2021) using oscillator motifs to generate bio-plausible neural activity (Talanov et al, 2020). We used a neuron circuit that consists of OMs to produce a bio-plausible pattern of neural activity.…”

Section: The Study Setupmentioning

confidence: 99%

“…The one-board computer generates the neuronal activity in realtime neurosimulation. The OM (Figure 2A) is a basic unit of the model and produces various durations of activity (Talanov et al, 2020) that depends on the balance of excitatory and inhibitory weights. We used the neuronal circuit with 3 OMs (Figure 2B) for stimulation since previously we had indicated that the 3 OM circuit is the most comfortable neuronal circuit for the participating volunteer (Talanov et al, 2021).…”

Section: The Study Setupmentioning

confidence: 99%

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Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles

Mikhailova

Pozdeeva

Suleimanova³

et al. 2023

Front. Neurosci.

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The effect of inhibitory management is usually underestimated in artificial control systems, using biological analogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio-plausible patterns. We proposed an approach for the compensatory stimulation device as implementation of previously presented architecture of the neurointerface, where (1) the neuroport is implemented as a DAC and stimulator, (2) neuroterminal is used for neurosimulation of a set of oscillator motifs on one-board computer. In the set of experiments with five volunteers, we measured the efficacy of motor neuron inhibition via the antagonist muscle or nerve stimulation registering muscle force with and without antagonist stimulation. For the agonist activation, we used both voluntary activity and electrical stimulation. In the case of stimulation of both the agonist and the antagonist muscles and nerves, we experimented with delays between muscle stimulation in the range of 0–20 ms. We registered the subjective discomfort rate. We did not identify any significant difference between the antagonist muscle and nerve stimulation in both voluntary activity and electrical stimulation of cases showing agonist activity. We determined the most effective delay between the stimulation of the agonist and the antagonist muscles and nerves as 10–20 ms.

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Section: The Study Setupmentioning

confidence: 99%

Section: The Study Setupmentioning

confidence: 99%

Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles

Mikhailova

Pozdeeva

Suleimanova³

et al. 2023

Front. Neurosci.

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“…More than that, attempts to compensate for spastic syndrome led to several devices developments [18], [19]. In this work we used the previously proposed approach for the neurointerface [14] using Oscillator Motifs to generate bio-plausible neural activity [20].…”

Section: A the Study Setupmentioning

confidence: 99%

“…The OM, (Fig. 2a) is a basic unit of the model and produces various duration of activity [20] that depends on balance of excitatory and inhibitory weights. We used the neuronal circuit with 3 OMs (Fig.…”

Section: A the Study Setupmentioning

confidence: 99%

Neurointerface with Oscillator Motifs for inhibitory effect over antagonist muscles for compensation of spastical syndrome

Mikhaïlova

Pozdeeva

Suleimanova

et al. 2022

Preprint

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The inhibitory management effect is usually un- derestimated in artificial control systems, using biological anal- ogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio plausible patterns. We proposed the approach for the compensatory stimulation device in development of previously presented archi- tecture of neurointerface, where (1) neuroport is implemented as DAC and stimulator, (2) neuroterminal – as neurosimulation of a set of oscillator motifs on one-board computer. In the set of experiments with 5 volunteers we measured the efficacy of motor neuron inhibition via antagonist muscle or nerve stim- ulation registering muscle force with and without antagonist stimulation. For the agonist activation, we used both voluntary activity and electrical stimulation. In the case of stimulation of both agonist and antagonist muscles and nerves, we exper- imented with delays between muscles stimulation starts in the range 0...20 ms. We registered the subjective discomfort rate. We didn’t identify a significant difference between antagonist muscle and nerve stimulation in both voluntary and stimulation of agonist activity. We determined the most effective delay between stimulation of agonist and antagonist muscle/nerve as 10–20 ms.

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“…The applied research of the neuromorphic and neurostimulation technology in the medical domain is at an early stage of development (Mikhaylov et al, 2020), and the topology of the spinal central pattern generator (CPG) itself is still under research (Rybak et al, 2015). Recently, we published works introducing a computational bio-compatible approach incorporating Oscillator Motif (OM)-the basic neuronal generator (Leukhin et al, 2020;Talanov et al, 2020). Later, we extended the use of OMs for the neurointerfaces (Talanov et al, 2021) and spasticity compensating devices (Mikhailova et al, 2022).…”

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confidence: 99%

Memristive circuit-based model of central pattern generator to reproduce spinal neuronal activity in walking pattern

Masaev

Suleimanova²,

Прудников³

et al. 2023

Front. Neurosci.

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Existing methods of neurorehabilitation include invasive or non-invasive stimulators that are usually simple digital generators with manually set parameters like pulse width, period, burst duration, and frequency of stimulation series. An obvious lack of adaptation capability of stimulators, as well as poor biocompatibility and high power consumption of prosthetic devices, highlights the need for medical usage of neuromorphic systems including memristive devices. The latter are electrical devices providing a wide range of complex synaptic functionality within a single element. In this study, we propose the memristive schematic capable of self-learning according to bio-plausible spike-timing-dependant plasticity to organize the electrical activity of the walking pattern generated by the central pattern generator.

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Oscillator Motif as Design Pattern for the Spinal Cord Circuitry Reconstruction

Cited by 6 publications

References 24 publications

Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles

Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles

Neurointerface with Oscillator Motifs for inhibitory effect over antagonist muscles for compensation of spastical syndrome

Memristive circuit-based model of central pattern generator to reproduce spinal neuronal activity in walking pattern

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