Oscillations in blood cells as a consequence of suppressed bone marrow cell production

Abstract

A hypothesis is proposed that the oscillations in blood cell numbers are the result of suppressed productivity of the bone marrow and its ability to satisfy both the demands of the erythroid and myeloid cell lines. The hypothesis is used as the basis for a mathematical model which describes the oscillations in all subpopulations of these cell lines. The relationship between the period and amplitude of the oscillations and the extent of suppression of the bone marrow productivity have been explored.

Cyclic Red Blood Cell Destruction in Thalassemia

“…Since we do not have long records of Hb destruction in healthy people, the answer can only be hypothetical. However, since it was shown that bone marrow suppression gives rise to oscillation in peripheral blood cells (32,33), it is quite possible that the condition of partial or total bone marrow suppression due the transfusional therapy may unmask a periodical RBC destruction mechanism that is normally hidden and intermingled with RBC production.…”