Oscillation dynamics of embolic microspheres in flows with red blood cell suspensions

Das, Tamal; Carugo, Dario; Zhang, Xunli; Chakraborty, Suman

doi:10.1063/1.4768889

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…These parameters will, in turn, affect bead mechanical properties [17] and deliverability via microcatheters. Furthermore, we have previously demonstrated that the fluid dynamics within the target vascular system can influence the flow behaviour of suspended embolic beads [33] and, ultimately, determine the spatial location of vascular occlusion sites [34]. The spatial location of embolic events has been observed to further depend on bead size and concentration in the embolic suspension, which was previously postulated by others but only qualitatively [35].…”

Section: Accepted M Manuscriptmentioning

confidence: 84%

Spatiotemporal dynamics of doxorubicin elution from embolic beads within a microfluidic network

Carugo

Capretto

Roy

et al. 2015

Journal of Controlled Release

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Anticancer treatment using embolic drug-eluting beads (DEBs) has shown multifarious advantages compared to systemic chemotherapy. However, there is a growing need for a better understanding of the physical parameters governing drug-elution from embolic devices under physiologically relevant fluidic conditions. In the present study, we investigated the spatiotemporal dynamics of doxorubicin hydrochloride elution from drug-loaded hydrogel embolic beads within a microfluidic device, consisting of a network of interconnected microchannels, which replicates the architectural properties of microvascular systems. Drug-elution has been investigated experimentally at a single-bead level, using in-house developed microscopy-and spectrofluorimetry-based methods. Results demonstrated that the kinetics of drug-elution and the amount of eluted drug strongly depended on the location of the embolic event within the embolised channel (e.g. fractional amount of eluted drug after 3 hours was equal to ~0.2 and ~0.6 for completely-confined and partially-confined bead, respectively). Drug-elution from partiallyconfined bead showed a counterintuitive dependence on the local Reynolds number (and thus on the mean fluid velocity), as a result of dynamic changes in bead compressibility causing the displacement of the bead from the primary embolic site. Conversely, the kinetics of drug-elution from fully-confined bead was less affected by the local Reynolds number and bead displayed faster elution from the surface area exposed to the systemic flow, which was associated with the formation of fluid eddies nearby the bead post embolisation.

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Section: Accepted M Manuscriptmentioning

confidence: 84%

Spatiotemporal dynamics of doxorubicin elution from embolic beads within a microfluidic network

Carugo

Capretto

Roy

et al. 2015

Journal of Controlled Release

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“…The physicochemical properties of microsphere suspensions have also been associated with the miscibility and distribution within hemodynamic flow . It has been proposed that microspheres will track to the distribution of injected solutions in blood .…”

Section: Suspension Handling and Microcatheter Delivery Of Microsphmentioning

confidence: 99%

Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab

Caine

Carugo

Zhang

et al. 2017

Adv Healthcare Materials

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Microspheres in Advanced Healthcare ApplicationsMicrospheres are small spherical particles with a diameter in the range 1-1000 µm, typically free-flowing in nature that can be made from either synthetic or natural materials (or a combination thereof). They have found widespread use in healthcare applications because numerous methods exist to manufacture Therapeutic embolotherapy is the deliberate occlusion of a blood vessel within the body, which can be for the prevention of internal bleeding, stemming of flow through an arteriovenous malformation, or occlusion of blood vessels feeding a tumor. This is achieved using a wide selection of embolic devices such as balloons, coils, gels, glues, and particles. Particulate embolization is often favored for blocking smaller vessels, particularly within hypervascularized tumors, as they are available in calibrated sizes and can be delivered distally via microcatheters for precise occlusion with associated locoregional drug delivery. Embolic performance has been traditionally evaluated using animal models, but with increasing interest in the 3R's (replacement, reduction, refinement), manufacturers, regulators, and clinicians have shown interest in the development of more sophisticated in vitro methods for evaluation and prediction of in vivo performance. Herein the current progress in developing bespoke techniques incorporating physical handling, fluid dynamics, occlusive behavior, and sustained drug elution kinetics within vascular systems is reviewed. While it is necessary to continue to validate the safety of such devices in vivo, great strides have been made in the development of bench tests that better predict the behavior of these products aligned with the principles of the 3R's.

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“…observed lateral oscillations of microspheres in pipe flow by microscopy that he referred to an increase of the hematocrit level, i.e. red blood cells 31 . They observed that these lateral oscillations contain higher harmonics of the rotational frequency 31 .…”

Section: Discussionmentioning

confidence: 99%

“…red blood cells 31 . They observed that these lateral oscillations contain higher harmonics of the rotational frequency 31 . Though the lateral oscillatory MM traces (cf.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive monitoring of blood flow using a single magnetic microsphere

Liebl

Gleich

Eberbeck

et al. 2019

Sci Rep

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Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter constrictions in an arteria phantom after a single passage of a microsphere. We further demonstrate the potential for clinical application by tracking a microsphere smaller than a red blood cell.

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Oscillation dynamics of embolic microspheres in flows with red blood cell suspensions

Cited by 3 publications

References 32 publications

Spatiotemporal dynamics of doxorubicin elution from embolic beads within a microfluidic network

Spatiotemporal dynamics of doxorubicin elution from embolic beads within a microfluidic network

Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab

Noninvasive monitoring of blood flow using a single magnetic microsphere

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