Osborne Allen Brines 1894–1960

Owen, Clarence I.

doi:10.1093/ajcp/34.4.371

Cited by 2 publications

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“…12 In the mid-1950s, the activated partial thromboplastin time (APTT) test, the thromboplastin generation test, the prothrombin consumption test, and the clot retraction test were added. 13 During these early years, Dr. Owen continued Dr. Nygaard's study of clot detection by optical spectrochemistry. He found that when a PT specimen was analyzed with spectrophotometry the change in optical density precisely matched the coagulation time.…”

Section: The Establishment and Rapid Growth Of The Clinical Coagulati...mentioning

confidence: 99%

A Brief History of Hemostasis and Thrombosis at the Mayo Clinic

Chen

Pruthi

2023

Semin Thromb Hemost

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Coagulation is a crucial biological mechanism in human bodies to prevent blood loss. Abnormal coagulation can cause bleeding diathesis or thrombosis, common pathologic conditions in our clinical practice. Many individuals and organizations have dedicated their efforts in the past decades to understanding the biological and pathological mechanisms of coagulation and developing laboratory testing tools and treatment options to help patients with bleeding or thrombotic conditions. Since 1926, the Mayo Clinic coagulation group has made significant contributions to the clinical and laboratory practice, basic and translational research on various hemostatic and thrombotic disorders, and the education and collaboration to share and advance our knowledge in coagulation through a highly integrated team and practice model. We would like to use this review to share our history and inspire medical professionals and trainees to join the efforts to advance our understanding of coagulation pathophysiology and improve our care for patients with coagulation disorders.

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Section: The Establishment and Rapid Growth Of The Clinical Coagulati...mentioning

confidence: 99%

A Brief History of Hemostasis and Thrombosis at the Mayo Clinic

Chen

Pruthi

2023

Semin Thromb Hemost

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show abstract

“…In 1904, Morawitz proposed the four-factor theory of coagulation, building upon the description of fibrinogen by Hammerstein and fibrin ferment (now more appropriately termed as thrombin) by Schmidt. 8,9 Mellanby summarized the understanding of the process as follows: "the coagulation of blood is due to the action of fibrin ferment on fibrinogen (factor I). Fibrin ferment does not circulate but is produced on tissue injury which liberates thrombokinase (factor III).…”

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confidence: 99%

Russell Viper Venom: A Journey from the Bedside to the Bench and Back to the Bedside

Thachil

2023

Semin Thromb Hemost

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Russel Viper Venom (RVV) is widely used as a diagnostic test for antiphospholipid syndrome (APS). But the history of how this venom came to be discovered is well known. Dr Patrick Russel is responsible for the identification of the venom during his work on snake bites in India while Dr Robert Macfarlane used it to staunch bleeding in persons with haemophilia. The ability to directly activate factor X led RVV to the laboratory diagnosis of APS. More recently, it has come back to clinical world with a potential for an engineered factor X activator from RVV to be used in the treatment of haemophilia.

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Osborne Allen Brines 1894–1960

Cited by 2 publications

References 0 publications

A Brief History of Hemostasis and Thrombosis at the Mayo Clinic

A Brief History of Hemostasis and Thrombosis at the Mayo Clinic

Russell Viper Venom: A Journey from the Bedside to the Bench and Back to the Bedside

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