Osborn wave in hypothermia and relation to mortality

Eroğlu, Oğuz; Serbest, Sancar; Kufeciler, Tarkan; Kalkan, Ahmet

doi:10.1016/j.ajem.2018.08.049

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Moreover, the presence of OW is reportedly associated with mortality in hypothermic patients. 21 We could not determine any significant relationship between the presence of OW and in-hospital mortality, despite adjusting for potential confounders in this study.…”

Section: Discussionmentioning

confidence: 67%

Osborn Wave Is Related to Ventricular Fibrillation and Tachycardia in Hypothermic Patients

Okada

Matsuyama

Morita

et al. 2020

Circ J

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Background: The Osborn wave (OW) is often observed in hypothermic patients; however, whether OW in hypothermic patients is related to the development of fatal ventricular arrhythmia, including ventricular fibrillation (VF) and pulseless ventricular tachycardia (VT), remains undetermined. This study aimed to estimate the association between OW and the incidence of fatal ventricular arrhythmias. Methods and Results: This retrospective study used the Japanese Accidental Hypothermia Network registry database and included 572 hypothermic patients. Patients were divided into the OW group (those with OW) and non-OW group (those without OW). The relationship between the development of fatal arrhythmias and presence of OW was assessed using the chi-squared test. All patients who developed VF/VT (n=10) had OW on electrocardiogram upon hospital arrival. The presence of OW had a sensitivity of 100%, specificity of 47.8%, positive predictive value of 4.0%, and negative predictive value of 100% for VF/VT development. The in-hospital mortality rate was 22.3% in the OW group and 21.2% in the non-OW group (P=0.781). Conclusions: OW was observed in all hypothermic patients with VF/VT. The occurrence of ventricular arrhythmias is highly unlikely in the absence of OW on the electrocardiogram. Although the presence of OW might be used to predict these fatal arrhythmias in hypothermic patients, there was no association between the presence of OW and in-hospital mortality.

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Section: Discussionmentioning

confidence: 67%

Osborn Wave Is Related to Ventricular Fibrillation and Tachycardia in Hypothermic Patients

Okada

Matsuyama

Morita

et al. 2020

Circ J

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“…As a systemic granulomatous disease, sarcoidosis can affect both the central and peripheral nervous systems with the neurological manifestations varying depending on the areas of disease involvement [6, 7]. Pituitary disease and hypothalamic involvement can result in severe endocrine dysfunction including panhypopituitarism and central diabetes insipidus and dysthermia (either hypothermia or hyperthermia), respectively, as were seen in this patient [4–7].…”

Section: Discussionmentioning

confidence: 90%

“…Osborn waves, or J waves, initially attributed to a hypothermia-induced “injury current,” have more recently been attributed to a differential between epicardial and endocardial potassium (I to ) currents creating a voltage gradient and the observed J wave [1, 2]. While not pathognomonic for hypothermia, the presence of J waves, most commonly seen in the anterior and lateral precordial leads, is highly sensitive and specific for hypothermia [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Cold at the Core: Osborn Waves in Neurosarcoidosis-Induced Central Hypothermia

Troutman

Salamon

Scharf

et al. 2019

Case Reports in Cardiology

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Osborn waves, or J waves, initially described by John Osborn in 1953 in hypothermic dog experiments, are highly sensitive and specific for hypothermia. Initially thought to be secondary to a hypothermia-induced “injury current,” they have more recently been attributed to a voltage differential between epicardial and endocardial potassium (Ito) currents. While the exact conditions required to induce such waves have been debated, numerous clinical scenarios of environmental and iatrogenic hypothermia have been described. Below, we report a novel case of hypothermia—that of neurosarcoidosis-induced central hypothermia with resultant Osborn waves and other associated findings found on electrocardiogram (ECG).

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