Abstract:Background: Although most meningiomas are non-malignant, there is a high recurrence rate among atypical and anaplastic (malignant) meningiomas (grades II/III). In addition, malignant meningioma usually progresses after treatment. Recently, based on DNA methylation, two subgroups of meningioma were described with recurrence-free survival differences (favorable and unfavorable). Epigenetic deregulation at distinct genomic elements such as enhancers can drive changes in gene expression and alter the transcription… Show more
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