Os Núcleos Vasomotores Do Bulbo E a Regulação Cardiovascular: Novas Evidências E Novas Questões

Cravo, Sérgio L.; Rosa, Daniel Alves; Kalassa, Fernanda; Korim, Willian S.; Hinrichs, Julia M.; Ferreira-Neto, Marcos L.; Mônaco, Luciana R. Di; Pedrino, Gustavo Rodrigues

doi:10.11606/issn.2176-7262.v39i1p89-100

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…The reflex response induced by baroreceptor modulates sympathetic activity to the heart, blood vessels, and adrenal medulla. Stimulation of baroreceptors often results in a decrease in sympathetic tone to heart and blood vessels ( Cravo et al, 2006 ). In the present study, the oral chronic administration of LQFM-21 did not alter baroreceptor reflex sensitivity in SHR.…”

Section: Discussionmentioning

confidence: 99%

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Trindade¹,

Lopes²,

Naves³

et al. 2018

Front. Physiol.

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The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications. The current study sought to investigate the antihypertensive effect of a newly synthesized pyrazole derivative known as 5-(1-(3 fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-21). Spontaneously hypertensive rats (SHR) were used to evaluate the effect of LQFM-21 on mean arterial pressure (MAP), heart rate (HR), renal vascular conductance (RVC), arterial vascular conductance (AVC), baroreflex sensitivity (BRS) index, and vascular reactivity. Acute intravenous (iv) administration of LQFM-21 (0.05, 0.1, 0.2, and 0.4 mg kg-1) reduced MAP and HR, and increased RVC and AVC. Chronic oral administration of LQFM-21 (15 mg kg-1) for 15 days reduced MAP without altering BRS. The blockade of muscarinic receptors and nitric oxide synthase by intravenous infusion of atropine and L-NAME, respectively, attenuated cardiovascular effects of LQFM-21. In addition, ex vivo experiments showed that LQFM-21 induced an endothelium-dependent relaxation in isolated aortic rings from SHR. This effect was blocked by guanylyl cyclase inhibitor (ODQ) and L-NAME. These findings suggest the involvement of muscarinic receptor and NO/cGMP pathway in the antihypertensive and vasodilator effects of LQFM-21.

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Section: Discussionmentioning

confidence: 99%

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Trindade¹,

Lopes²,

Naves³

et al. 2018

Front. Physiol.

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“…Grandes evidências sugerem que a região rostroventrolateral do bulbo (RVL), uma importante região do sistema nervoso central responsável por excitar tonicamente neurônios simpáticos pré-ganglionares localizados na coluna intermédio-lateral regulando a atividade simpática para o sistema cardiovascular, seja modulada por espécies reativas de oxigênio, aumentando a transmissão simpática e, portanto, corroborando para a piora do estado clínico em indivíduos com IC [11][12][13][14][15][16] . Acredita-se que um aumento na atividade nervosa simpática possua um importante papel no desenvolvimento de algumas doenças cardiovasculares como, por exemplo, insuficiência cardía-ca e hipertensão arterial 17,18 .…”

Section: Introductionunclassified

Insuficiência cardíaca e atividade física: o aumento de enzimas antioxidantes e a melhora da atividade nervosa simpática

Gonçalves

Valenti

Ferreira

et al. 2010

Arq. Bras. Ciên. Saúde

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ResumoA insuficiência cardíaca vem se tornando um problema cada vez maior em saúde pública, e uma das principais causas de internações hospitalares em todo o mundo.Mesmo com os progressos médicos e os avanços tecnológicos atuais, a prevalência da doença aumentou nas últimas cinco décadas. Estudos recentes com animais mostraram que existe uma relação entre hiperatividade simpática na insuficiência cardíaca e aumento do estresse oxidativo sistêmico e central. Este trabalho tem como objetivo analisar, por meio de revisão bibliográfica, os benefícios produzidos pela atividade física em pacientes portadores de insuficiência cardíaca. Foram revisados estudos relacionados ao estresse oxidativo, controle neural da circulação, insuficiência cardíaca e exercício físico entre outubro de 2009 e abril de 2010 nas bases de dados: Medline, Pubmed e Lilacs. As referências eram datadas de 1986 a 2010. Utilizaram-se os seguintes termos: "Oxidative Stress", "Chronic Heart Failure", "Baroreflex", "Nervous System" and "Exercise". Ratos com insuficiência cardíaca induzida possuem um aumento de espécies reativas de oxigênio na região rostroventrolateral do bulbo, assim como comprometimento na atividade simpática. Alguns estudos sugerem que a atividade física normaliza a atividade simpática por meio de seus mecanismos antioxidantes em seres humanos. Outro aspecto interessante é que a atividade física reduz os níveis plasmáticos de angiotensina II, regula a disfunção do baroreflexo arterial e promove o aumento de enzimas antioxidantes no músculo esquelético de pacientes com insuficiência cardíaca. Portanto, conclui-se que a atividade física é um regime terapêutico não-farmacológico de extrema importância para pacientes com insuficiência cardíaca.Palavras-chave: Insuficiência cardíaca; estresse oxidativo; exercício físico; sistema neural. AbstractHeart failure is an increasing problem in public health, and a major cause of hospitalization worldwide. Even with the medical progress and technological advances in the present, the prevalence of the disease increased in the last five decades. Recent animal studies have shown that there is a relationship between sympathetic hyperactivity in heart failure and increased oxidative stress, systemic and central. This paper aims to examine, through literature review, the benefits of physical activity in patients with heart failure. We reviewed studies related to oxidative stress, neural control of circulation, heart failure and exercise between October 2009 and April 2010, on the databases: Medline, Pubmed e Lilacs. The references dated from 1986 to 2010, and we used the following terms: "oxidative stress", "chronic heart failure", "baroreflex", "nervous system" and "exercise". Rats with induced heart failure have an increase of reactive oxygen species in the rostroventrolateral medula, and impairment of sympathetic activity. Some studies suggest that physical activity normalizes the sympathetic activity through its antioxidant mechanisms in the rostroventrolateral medulla. Some studies suggest that ...

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Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

Cravo

Campos

Colombari

et al. 2009

An. Acad. Bras. Ciênc.

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Several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. Our current understanding of this circuitry derives mainly from the studies of Pedro Guertzenstein, a former student who became Professor of Physiology at UNIFESP later, and his colleagues. In this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions.

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Os Núcleos Vasomotores Do Bulbo E a Regulação Cardiovascular: Novas Evidências E Novas Questões

Cited by 4 publications

References 39 publications

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Insuficiência cardíaca e atividade física: o aumento de enzimas antioxidantes e a melhora da atividade nervosa simpática

Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

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