“…1 The use of oligonucleotides has been considered a new strategy for the treatment of malaria given the fact that these single strand nucleic acids can interfere in protein synthesis, thus inhibiting parasite growth. 2,3 However, the use of oligonucleotides is hampered in vivo due to their very low penetration ability 4,5 and susceptibility against nuclease degradation. 6,7 In addition to chemical modifications, oligonucleotides association with positively-charged colloidal carriers has been extensively investigated to circumvent such drawbacks.…”