Oryeongsan (Goreisan) Ameliorates Experimental Autoimmune Encephalomyelitis

Inada, Rino; Miyamoto, Katsuichi; Tanaka, Noriko; Moriguchi, Kota; Kusunoki, Susumu

doi:10.2169/internalmedicine.3030-19

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…It is used to adjust the body's water balance by inhibiting mainly AQP4 channels and other AQP subtypes [ 11 ]. AQP3, 4, and 5 upregulates chemokine production [ 12 ], and Goreisan has a potent anti-inflammatory effect inhibiting these AQPs [ 13 ]. This anti-inflammatory may have somehow improved orthostatic pain.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Intracranial Hypotension Manifesting Orthostatic Headache Worsened by Playing the Saxophone and Treated by Japanese Herbal Kampo Medicine Goreisan

Katsuki¹,

Kashiwagi²,

Kawamura³

et al. 2022

Cureus

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We present a 15-year-old Japanese girl with no previous medical history who presented with a gradually worsening series of orthostatic headaches. We diagnosed spontaneous intracranial hypotension, worsened by playing the saxophone and its Valsalva maneuver effect. She was treated with Japanese herbal Kampo medicine Goreisan 7.5 g/day in three divided doses, and her symptoms gradually improved. Her headache has never recurred for a year when she played the saxophone. Our case’s headache may have been further exacerbated by cerebrospinal fluid (CSF) leakage due to CSF pressure increase by Valsalva maneuvers while playing the saxophone. Our case suggested that the Japanese herbal Kampo medicine Goreisan can facilitate the glymphatic system and adjust the CSF pressure appropriately.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Intracranial Hypotension Manifesting Orthostatic Headache Worsened by Playing the Saxophone and Treated by Japanese Herbal Kampo Medicine Goreisan

Katsuki¹,

Kashiwagi²,

Kawamura³

et al. 2022

Cureus

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“…Goreisan (TJ-17) is composed of five herbal components and is used to adjust the water balance of the body by inhibiting mainly aquaporin 4 (AQP4) [ 13 ] channels as well as other AQP subtypes. AQP3, 4, and 5 upregulate chemokine production [ 14 ], and goreisan has a potential anti-inflammatory effect by inhibiting AQPs [ 15 ]. Also, there is a glymphatic system in the cranium, which drains inflammatory substances, suppresses inflammation and pain, protects the brain, and prevents brain edema.…”

Section: Discussionmentioning

confidence: 99%

Medication Overuse Headache Successfully Treated by Three Types of Japanese Herbal Kampo Medicine

Katsuki¹,

Kawamura²,

Kashiwagi³

et al. 2021

Cureus

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Medication overuse headache (MOH) usually resolves after the overuse is stopped and starting prophylactic medications. However, it can be challenging to prescribe common prophylactic medications when patients have a history of side effects. As an alternative therapy, traditional Japanese herbal kampo medicine can be used. We herein report a case of a MOH woman with a history of side effects by such common prophylactic medications. A 50-year-old woman presented with a severe migraine attack. She had suffered from migraines for 10 years. She had taken loxoprofen and sumatriptan every day for over eight years. As prophylactic medications, lomerizine, valproic acid, and amitriptyline had been prescribed in the past, but they were discontinued due to side effects. Therefore, she could continue only propranolol as prophylactic medication. She had severe pulsatile headaches and nausea every day. We diagnosed triptan-and nonsteroidal anti-inflammatory drug-overuse headache (the International Classification of Headache Disorders 3rd edition code 8.2.2 and 8.2.3.2) and chronic migraine (code 1.3). She was admitted and stopped loxoprofen and sumatriptan. We prescribed three types of Japanese herbal kampo medicines -kakkonto (TJ-1), goreisan (TJ-17), and goshuyuto (TJ-31). Her headache was relieved on day 5, and she was discharged on day 7. In the 40 days after discharge, she had only three times mild headaches with a numeric rating scale (NRS) of 2/10. She did not need any triptans nor anti-inflammatory drugs. We herein presented the MOH woman who was successfully treated using three types of kampo medicine. We should pay attention to their side effects, but kampo medicine may be useful for MOH treatment as acute and prophylactic medications for primary headaches.

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“…Aquaporin (AQP) is a water channel and is composed of at least 13 types of isoforms. Goreisan strongly inhibits AQP3, AQP4, and AQP5 [ 9 , 10 ]. Interestingly, unlike western diuretics, Goreisan induces an increase of urine volume in an edematous state, but not in a dehydrated state.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Saireito, a Traditional Japanese Kampo Herbal Medication, on Pacemaker-Related Pleural Effusion: A Case Report

et al. 2021

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Patient: Female, 71-year-old Final Diagnosis: Pacemaker related pleural effusion Symptoms: Dry cough Medication:— Clinical Procedure: — Specialty: Cardiology • General and Internal Medicine Objective: Unusual or unexpected effect of treatment Background: Post-cardiac injury syndrome, including pleural effusion as a delayed complication of permanent pacemaker implantation, has rarely been reported. To resolve pleural effusion, prolonged chest tube placement is often required. Anti-inflammatory agents combined with diuretics are also often prescribed. Saireito, a Japanese herbal medication, which is a combination of Goreisan and Shousaikoto, has both anti-inflammatory and water-modulation properties and has been used for edema (lymph edema, cerebral edema) and inflammation (chronic nephritis). Case Report: We describe a 71-year-old woman with a history of syncope and bradycardia who underwent dual permanent pacemaker implantation (placed in the right chest because of a persistent left superior vena cava) without complications. Two months later, she came to the hospital as an outpatient with a dry cough, and was diagnosed with right-sided pleural effusion. A pleural fluid analysis revealed exudative effusion, according to Light’s criteria. The fluid was negative for infectious etiology. Chest X-ray, computed tomography, and echocardiography revealed no signs of pericardial effusion or perforation of the pacemaker lead to outside the heart. The pleural effusion persisted despite use of anti-inflammatory medication for several weeks and diuretics for a short period. Saireito was administered with good response; the pleural effusion resolved completely and there was no deterioration of renal function. Conclusions: The present case highlights the clinical significance of Saireito as an effective therapeutic agent for late-onset pacemaker-related pleural effusion, without adverse effects such as renal dysfunction.

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Oryeongsan (Goreisan) Ameliorates Experimental Autoimmune Encephalomyelitis

Cited by 7 publications

References 16 publications

Spontaneous Intracranial Hypotension Manifesting Orthostatic Headache Worsened by Playing the Saxophone and Treated by Japanese Herbal Kampo Medicine Goreisan

Spontaneous Intracranial Hypotension Manifesting Orthostatic Headache Worsened by Playing the Saxophone and Treated by Japanese Herbal Kampo Medicine Goreisan

Medication Overuse Headache Successfully Treated by Three Types of Japanese Herbal Kampo Medicine

Effectiveness of Saireito, a Traditional Japanese Kampo Herbal Medication, on Pacemaker-Related Pleural Effusion: A Case Report

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