Orthotopic liver transplantation in knockout mice: is TNFα involved in early graft injury and regeneration?

PPARα is down-regulated following liver transplantation in mice

“…However, in this study, we used the mouse transplantation model established by Qian et al [31]. This model was first reported in 1991 and generally recognized as a valid liver transplantation model [32][33][34][35][36][37][38][39][40]. Unlike the conventional ischemia/reperfusion models ,liver grafts removed from recipients were perfused and kept in cold Ringer's solution or physiological saline until finishing removal of donors' livers and the suture of vasculatures was completed as soon as possible to minimize total ischemic time.…”

Steatotic liver transplantation in the mouse: a model of primary nonfunction

“…The procedure on which this model is based is the nonarterialized transplant model, as described by Qian et al in 1991 [1], which has served as a valid model for numerous publications since that time [7][8][9][10][11][12]. Since the completion of this work, Tian et al have described an arterialized liver transplant model in the mouse, and an improved outcome with arterialization [2].…”