Orthotopic Liver Transplantation in a Patient With a Giant Cavernous Hemangioma of the Liver and Kasabach-Merritt Syndrome

Klompmaker, I. J.; Mj, Slooff; Vandermeer, J; Dejong, Gmt; Debruijn, Km; Bams, J. L.

doi:10.1097/00007890-198907000-00035

Cited by 42 publications

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“…The well-known Kasabach-Merrit syndrome, which involves coagulopathy with fibrinolysis and thrombocytopenia associated with an hemangioma, 8 is also uncommon: 1 of 114 patients in the series of Iwatsuki et al, 2 2 of 109 patients in the series of Farges et al, 9 2 of 26 patients in the series of Egea et al, 10 and 2 of 24 patients in the series of Belli et al 5 In a few patients with contraindications to surgical excision, severe coagulation disorders have led to liver transplantation. 11,12 None of our patients presented signs of KasabachMerrit syndrome, and one presented with thrombocytosis related to the inflammatory process. Complications are generally uncommon in patients under observation for symptom-free giant LH.…”

Section: Discussionmentioning

confidence: 77%

Inflammatory process complicating giant hemangioma of the liver: Report of three cases

et al. 1998

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Three cases of giant hemangioma of the liver associated with clinical and laboratory signs of inflammatory process, including low-grade fever, weight loss, abdominal pain, accelerated erythrocyte sedimentation rate, anemia, thrombocytosis, and increased fibrinogen level with normal white blood cell count are described. One patient presented with slight cholestatic jaundice because of tumor-related bile duct compression, but the other two patients had normal liver function tests, except for a slight increase in gammaglutamyl transferase. Clinical and laboratory abnormalities disappeared after surgical excision. Inflammatory manifestations have rarely been reported during giant liver hemangioma. Intratumoral inflammation necrosis or bleeding could explain the symptoms but histological signs of inflammation were not detected in two of three surgical specimens. The release of immune mediators by liver endothelial cells lining the hemangioma is an alternative explanation. The incidence of inflammatory process complicating giant hemangioma is probably underestimated because our three cases were observed within a span of only 3 years.

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Section: Discussionmentioning

confidence: 77%

Inflammatory process complicating giant hemangioma of the liver: Report of three cases

et al. 1998

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“…"# .. 11[·*_1------Excellent long-term outcome after elective liver transplantation [or large. life-threatening.…”

Section: Focal Nodular Hyperplasiamentioning

confidence: 99%

Orthotopic Liver Transplantation for Benign Hepatic Neoplasms

Tepetes

Selby²,

Webb³

et al. 1995

Arch Surg

109

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Obiective: To evaluate the frequency and outcome of liver transplantation for symptomatic, unresectable. benign hepatIc neoplasms.hepatic lymphangiomatosis (n= 1), hilar fibrous angiodysplasia (n= 1). focal nodular hyperplasia (n= 1). and hemanglOma (n= I). There were three perioperative deaths and two late deaths at 56 and 84 months. The remaining patients are alive. 'With follow-up ranging from 36 to 145 months. Median survival for the nine patients who survived the perioperatIve period is 88 months. The early deaths were attributable to hemorrhagic complications (n=2) and necrotizing pancreatitis (n=1). The two late deaths were due to disseminated aspergillosis and hepatitis-associated cirrhosis.

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“…18 There have been several reports of large amounts of blood loss, such as 18.5 l in one case and 16 l in another. 19 To prevent tumor rupture and excessive blood loss during dissection, the Pringle maneuver, 19 venovenous bypass, 19 and early division of the hepatic arteries 18 have been performed. However, there has only been a case report of giant cavernous hepatic hemangiomas without KMS.…”

Section: Discussionmentioning

confidence: 96%

Living donor liver transplantation in a patient with giant hepatic hemangioma complicated by Kasabach-Merritt syndrome: Report of a case

et al. 2008

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We herein present a case of unresectable giant hepatic hemangiomas with Kasabach-Merritt syndrome which was successfully treated by living donor liver transplantation using a left lobe graft. The patient was a 45-year-old woman who complained of abdominal distension. Two sessions of transarterial embolization were performed, but failed to reduce the size of the tumor. The hepatic tumors were thus judged untreatable and the only option for a cure was to offer living donor liver transplantation, because of the tumor size, its location, and the association with Kasabach-Merritt syndrome. A left lobe graft with the middle hepatic vein donated by her 47-year-old brother was transplanted under venovenous bypass. The postoperative course of the recipient was complicated by small-for-size graft syndrome, which developed after episodes of acute cellular rejection on postoperative day 8 and sepsis on day 31. The patient successfully recovered from the complications and was discharged on day 72, and she remains well at 10 months after transplantation. In conclusion, living donor liver transplantation was found to be an effective option for the treatment of a patient with unresectable giant hepatic hemangiomas complicated by Kasabach-Merritt syndrome.

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Orthotopic Liver Transplantation in a Patient With a Giant Cavernous Hemangioma of the Liver and Kasabach-Merritt Syndrome

Cited by 42 publications

References 0 publications

Inflammatory process complicating giant hemangioma of the liver: Report of three cases

Inflammatory process complicating giant hemangioma of the liver: Report of three cases

Orthotopic Liver Transplantation for Benign Hepatic Neoplasms

Living donor liver transplantation in a patient with giant hepatic hemangioma complicated by Kasabach-Merritt syndrome: Report of a case

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