Orthotopic ileal neobladder reconstruction in a woman who developed squamous cell carcinoma of the urinary bladder after kidney transplantation

Abstract

The case of a 62-year-old woman who developed squamous cell carcinoma of the bladder 16 years after a kidney transplant is reported here. After the transplant, immunosuppressive therapy was maintained with cyclosporin A (200 mg/day) and the patient's serum creatinine level was 0.9 mg/dL. She was diagnosed with squamous cell carcinoma of the bladder 16 years later and underwent radical cystectomy with an orthotopic ileal neobladder. The Studer technique was used and the afferent ileal loop was anastomosed to the graft ureter. The postoperative course was uneventful. At the 6-month follow-up visit, the patient showed no evidence of recurrence. Her serum creatinine level was 1.0 mg/dL. The patient was continent during the day and the night. This case shows that the construction of an orthotopic ileal neobladder after cystectomy is safe and feasible in kidney transplant recipients.

Radical Cystectomy and Ileal Conduit Diversion for Bladder Urothelial Carcinoma With Sarcomatoid and Squamous Variants After Renal Transplantation

“…In the literature, studies on the sarcomatoid variant in bladder cancer after kidney transplantation are rare [13,14]. Also, squamous cell bladder carcinoma has been reported in a limited number of cases after kidney transplantation [15,16]. As we know, our case is the first report in the literature to describe both sarcomatoid and squamous variants in bladder cancer after renal transplantation.…”

“…There is no clear consensus on the type of urinary diversion in patients with renal transplant recipients. However, since orthotopic neobladder is more favorable in terms of patient comfort, orthotopic neobladder has been the preferred method in recent studies [16,17]. However, the orthotopic neobladder method may have more problems such as frequent urinary tract infections due to intermittent catheterization and the development of metabolic complications due to increased urine absorption from the intestinal urinary diversion [17].…”

Invasive squamous cell bladder cancer of the ureterovesical junction in a renal transplant patient: a case report

“…There appears to be only one report in the literature describing renal tuberculosis requiring nephrectomy and the subsequent development of squamous cell carcinoma of the bladder following transplantation [ 10 ]. Whether either of these patients were at a greater risk of developing squamous cell cancer of the bladder pre-transplant is unclear, but nevertheless an interesting query for meaningful investigation.…”

Malignant disease in renal transplant recipients: Our experience

“…The single cases of the orthotopic ileal neobladder reconstruction in patients with squamous cell carcinoma of the bladder have been reported. It has been shown that this procedure is safe and feasible in kidney transplant 7 .…”