Orthotopic Autologous Chondrocyte Grafting as a Method of Treatment of Growth Plate Damage in Rabbits

Tomaszewski, Ryszard; Wiktor, Łukasz; Gap, Artur

doi:10.5604/15093492.1226594

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…44 Similarly, Tomaszewski et al utilized a cartilage-fiber structure containing autologous growth plate cartilage to repair growth plate injury, resulting in good graft morphology and integration, without inflammatory reactions and with good recovery of the growth plate structure. 45 Another study found that implanting autologous growth plate cells into growth plate defects can prevent bone bridge formation while reducing growth arrest and angular deformity. 46 Additionally, Tobita et al extracted autologous chondrocytes from knee joint cartilage, embedded them in atelocollagen for 1 week, and then implanted them into the growth plate defect, where the implanted chondrocytes proliferated and secreted ECM.…”

Section: Growth Plate Regeneration Treatment Based On Tissue Engineer...mentioning

confidence: 99%

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

et al. 2023

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The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.

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Section: Growth Plate Regeneration Treatment Based On Tissue Engineer...mentioning

confidence: 99%

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

et al. 2023

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“…Since the most abundant cell type in the GP is chondrocytes, it is quite rational to implant chondrocytes in cartilage tissue engineered scaffolds for treatment of GP injuries ( Lee et al, 2016 ; Tomaszewski et al, 2016 ). Chondrocytes can also be obtained from different compartments in autograft or allograft.…”

Section: Cartilage Tissue Engineering For Gp Injuriesmentioning

confidence: 99%

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g., bone bridge resection and fat engraftment) always result in bone bridge formation, which will cause length discrepancy and angular deformity, thus making satisfactory outcomes difficult to achieve. The introduction of cartilage repair theory and cartilage tissue engineering technology may encourage novel therapeutic approaches for GP repair using tissue engineered GPs, including biocompatible scaffolds incorporated with appropriate seed cells and growth factors. In this review, we summarize the physiological structure of GPs, the pathological process, and repair phases of GP injuries, placing greater emphasis on advanced tissue engineering strategies for GP repair. Furthermore, we also propose that three-dimensional printing technology will play a significant role in this field in the future given its advantage of bionic replication of complex structures. We predict that tissue engineering strategies will offer a significant alternative to the management of GP injuries.

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Rabbit Model of Physeal Injury for the Evaluation of Regenerative Medicine Approaches

Rodríguez-Fontán

Eckstein

et al. 2019

Tissue Engineering Part C: Methods

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Orthotopic Autologous Chondrocyte Grafting as a Method of Treatment of Growth Plate Damage in Rabbits

Cited by 4 publications

References 17 publications

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review

Rabbit Model of Physeal Injury for the Evaluation of Regenerative Medicine Approaches

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