Orthostatic paroxysmal dystonia

Sethi, Kapil D.; Lee, Ki Hyeong; Deuskar, Vasanti; Hess, David C.

doi:10.1002/mds.10182

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Other Miscellaneous Episodic Movement Disorders1

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2011

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Cited by 13 publications

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“…Orthostatic paroxysmal dystonia refers to attacks provoked by assuming an upright position after sitting or lying 59. Vascular changes were present on MRI in the case described.…”

Section: Other Miscellaneous Episodic Movement Disordersmentioning

confidence: 79%

Paroxysmal dyskinesias

Bhatia¹

2011

Movement Disorders

156

127

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Paroxysmal movement disorders are a relatively rare and heterogenous group of conditions manifesting as episodic dyskinesia lasting a brief duration. Three forms are clearly recognized, namely, paroxysmal kinesigenic (PKD), nonkinisegenic (PNKD), and exercise induced (PED). There have been major advances in the understanding of the pathophysiological mechanisms and the genetics of these disorders, leading to better clinical definitions based on genotype-phenotype correlations in the familial idiopathic forms. PKD is genetically heterogenous, but there is linkage to chromosome 16 in a number of families. PNKD is due to mutations of the MR-1 gene. PED is genetically heterogenous, but a number of familial and sporadic cases may be due to GLUT-1 gene mutations. The GLUT1 gene-related form of PED may respond to a ketogenic diet. Potassium and calcium channel mutations underlie the 2 main forms of episodic ataxia (EA1 and EA2), whereas benign torticollis of infancy may also be a calcium channel disorder.

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“…Orthostatic paroxysmal dystonia refers to attacks provoked by assuming an upright position after sitting or lying 59. Vascular changes were present on MRI in the case described.…”

Section: Other Miscellaneous Episodic Movement Disordersmentioning

confidence: 79%