Orthostatic Intolerance in Behcet's Disease

Tellioǧlu, Tahir; Robertson, David

doi:10.1016/s1566-0702(01)00243-0

Cited by 8 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to systemic autoimmune diseases, POTS has been associated with autoimmune thyroid disease, and thyroid autoantibodies are found at a significantly higher prevalence than healthy controls (Blitshteyn, 2015;Raj et al, 2016;Singer et al, 2014). POTS has also been reported in association with antiphospholipid antibody syndrome (Schofield et al, 2014), chronic inflammatory demyelinating polyneuropathy (Adamec et al, 2016), multiple sclerosis (Kanjwal et al, 2010;Habek et al, 2017), Bechet's disease (Tellioglu and Robertson, 2001), and a high prevalence of antibodies recognized in autoimmune diseases (Blitshteyn, 2015).…”

Section: Association With Autoimmune Disordersmentioning

confidence: 98%

Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding

Vernino

Stiles²

2018

Autonomic Neuroscience

View full text Add to dashboard Cite

There is growing interest in the role of autoimmunity in postural orthostatic tachycardia syndrome (POTS). In recent years, investigators have described an increased rate of co-morbid autoimmune disease, and the presence of several neural receptor autoantibodies and non-specific autoimmune markers in POTS. Case reports on the efficacy of immunotherapy in highly selected POTS patients continue to appear in the literature, while no prospective clinical trials have occurred to date. This article summarizes the current state of knowledge on the role of autoimmunity in POTS, the clinical implications of these findings, and prospects for future research.

show abstract

Section: Association With Autoimmune Disordersmentioning

confidence: 98%

Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding

Vernino

Stiles²

2018

Autonomic Neuroscience

View full text Add to dashboard Cite

show abstract

“…Autonomic abnormalities were also detected by RRIV tests and a pupil light reflex test in the present patient. The Valsalva maneuver was reported to objectively reveal orthostatic intolerance in a patient with BD (27). There seems to be only one previous case report of a patient with BD whose autonomic disorders were evaluated using the HUT (29).…”

Section: Discussionmentioning

confidence: 99%

“…Some cardiovascular agonists, such as β-blockers, have been used to treat orthostatic intolerance (27). However, the necessity of immunotherapy for autonomic disorders associated with BD has not been established thus far.…”

Section: Discussionmentioning

confidence: 99%

Behçet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster

et al. 2020

View full text Add to dashboard Cite

A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.

show abstract

“…Aksoyek et al [36] reported that BS patients had increased sympathetic and decreased parasympathetic modulation, and they suggested that BS patients may have asymptomatic autonomic nervous system dysfunction. Moreover, Tellioglu and Robertson [37] described autonomic dysfunction accompanied by abnormal catecholamine levels in a BS patient, and they suggested that immunological damage to the components of neural pathways may contribute to the pathogenesis of the autonomic involvement. Sympathetic and parasympathetic autonomic dysfunction in patients with BS have been more recently confirmed [38,39], which may be related to disease activity.…”

Section: Behçet's Syndrome and The Stress Systemmentioning

confidence: 99%

Epidemiology and Management of Neuropsychiatric Disorders in Behçet’s Syndrome

et al. 2015

View full text Add to dashboard Cite

Behçet's syndrome (BS) is a systemic, chronic, relapsing vasculitis, typically characterized by recurrent orogenital ulcers, ocular inflammation and skin manifestations; articular, vascular, gastroenteric and neurological involvement may also occur. Besides the other clinical features of BS, it seems relatively frequent that patients with BS develop a neurobehavioural syndrome, characterized by euphoria, bipolar disorders and paranoid attitudes, loss of insight/disinhibition, and indifference to their disease, defined as 'neuro-psycho-BS'. To date, the pathogenetic mechanism underlying neuro-psycho-BS has not been determined. It may be secondary to organic neurological involvement, or it may be related to poor quality of life and the relapsing course of the disease. Another engaging theory suggests that it could be related to the frequent observation of psychiatric symptoms during relapses or, in some cases, in the phases preceding reactivation of the disease; these elements suggest that psychiatric disorders in BS could represent a crucial element, whether a psychiatric subset or a distinct clinical feature of the disease. Moreover, it has been reported that cognitive impairment in BS can be seen with or without central nervous system involvement. Globally, psychiatric symptoms have been described as being multifaceted, ranging from anxiety disorders to depressive-bipolar disorders or to psychotic ones. In addition, some psychological characteristics of BS patients seem to predispose them to maladaptive stress management, which may lead to stress-related disorders, including anxiety and depression. Therefore, the aims of this review are to explore the epidemiology of neuro-psycho-BS by evaluating the relationship between the stress system and the multifaceted psychiatric manifestations in BS, and to summarize the therapeutic strategy used.

show abstract

Orthostatic Intolerance in Behcet's Disease

Cited by 8 publications

References 18 publications

Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding

Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding

Behçet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster

Epidemiology and Management of Neuropsychiatric Disorders in Behçet’s Syndrome

Contact Info

Product

Resources

About