Orthostatic Hypotension Due to Arterial Baroreflex Failure

Timmers, Henri J L M; Wieling, Wouter; Karemaker, John M.; Lenders, Jacques W.M.

doi:10.1002/9780470995013.ch50

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The Baroreflex In Hypertension -Pre-clinical Studies1

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2008

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“…The baroreflex is a negative feedback mechanism for blood pressure regulation and its physiology is well established. 24,25 An increase in BP activates the baroreceptors present in the carotid sinus and aortic arch, 26 which ultimately leads to decreased sympathetic activity in the heart, peripheral vasculature and kidneys and increased parasympathetic activity in the heart. These effects lead to a decrease in blood pressure.…”

Section: The Baroreflex In Hypertension -Pre-clinical Studiesmentioning

confidence: 99%

Baroreflex Activation in Drug-resistant Hypertension

Kroon¹,

Leeuw²

2008

European Cardiology Review

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Hypertension is a common and serious problem that is the major cause of morbidity and mortality worldwide. [1][2][3] Over 70 million people in the US are affected by high blood pressure (BP) that requires treatment, and nearly one-third of the adult population in the US have a BP of ≥140/90mmHg, which is the defined cut-off value for hypertension. 2,4 It is estimated that over 44% of people in Europe are affected by high blood pressure. 5 Studies have shown that there are several risk factors for hypertension, including body mass index (BMI), 6,7 cholesterol, 8 age, 7 family history, 7 gender, 9 race/ethnicity 10 and a sedentary lifestyle. 6,11 Although there are many effective pharmacotherapies available, nearly 35% of patients with hypertension have a form that cannot be controlled by medication. 12,13

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Section: The Baroreflex In Hypertension -Pre-clinical Studiesmentioning

confidence: 99%