Orthostatic hypotension and health-related quality of life among community-living older people in Korea

Kim, Nahyun; Park, Jooyeon; Hong, Hyun-Jung; Kong, In Deok; Kang, Hyun-Wook

doi:10.1007/s11136-019-02295-6

Cited by 10 publications

(13 citation statements)

References 49 publications

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“…Orthostatic hypotension (OH) is associated with an increased risk of negative health consequences including cardiovascular diseases, falls, mortality, and cognitive impairment (Kim et al, 2020). However, the present study results revealed that; bolus of water intervention was effective in reducing OH and related symptoms (Table 2).…”

Section: Discussioncontrasting

confidence: 54%

Effect of Nursing Interventions on the Severity of Orthostatic Hypotension among Older Adults Residing in Assisted Living Facilities

Gamaa

Ibrahim

Abdelaziz

2021

Alexandria Scientific Nursing Journal

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Section: Discussioncontrasting

confidence: 54%

Effect of Nursing Interventions on the Severity of Orthostatic Hypotension among Older Adults Residing in Assisted Living Facilities

Gamaa

Ibrahim

Abdelaziz

2021

Alexandria Scientific Nursing Journal

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“…Hypotension manifests as dizziness, fatigue, blurred vision, and even falls in patients with PD, which could be a major cause of disability and a determinant of quality of life. Patients who lose self-care ability are a huge burden on caregivers and the health care economic system ( Ricci et al, 2015 ; Fanciulli et al, 2020 ; Kim et al, 2020 ). Therefore, monitoring BP is a vital part of the daily management of patients with PD.…”

Section: Introductionmentioning

confidence: 99%

Effect of Acute Levodopa Up-Titration on Blood Pressure in Patients With Early Stage Parkinson’s Disease: Results of a Levodopa Challenge Test

Zhang

et al. 2022

Front. Aging Neurosci.

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Objective: Levodopa up-titration is the primary therapeutic strategy as the Parkinson’s disease (PD) progresses. However, the effects of levodopa up-titration on blood pressure (BP) are inconclusive. This study aimed to investigate the effect of acute levodopa up-titration simulated by levodopa challenge test (LCT) on BP in patients with early stage PD.Methods: We monitored BP in 52 patients with early stage PD using a standardized standing test. BP was assessed in supine position after 10 min of rest and at 1 and 3 min after standing up. BP was measured in the “off-state” and the best “on-state” during LCT in the morning at hospital. In another day, “off-state” and the best “on-state” BP was measured before and after anti-PD drug uptake in the morning at home. Demographic and clinical features of the patients were evaluated and analyzed.Results: In the LCT, the prevalence of OH in the “off-state” and the best “on-state” was 11.5 and 13.5%, respectively. Additionally, the OH in the best “on-state” was associated with OH in the “off-state” and monoamine oxidase B inhibitor use. Although 38 (73.1%) patients experienced levodopa-induced hypotension during the LCT, no risk factors were identified. While BP reductions were observed after taking anti-PD drugs at home, no further reduction was seen during acute levodopa up-titration simulated by the LCT.Conclusion: Our results demonstrate that acute levodopa up-titration does not exacerbate BP reduction induced by anti-PD drugs at home. BP monitoring is critical for the management of patients with PD.

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“…Another study found higher prevalence rates for anxiety and depression (33 vs. 11%) and more problems in the discomfort and mobility dimensions, in people suffering from orthostatic intolerance, compared to those without. These effects are probably driven by dizziness, fatigue, and decreased memory ( 23 ). It has also been shown that xerostomia ( 24 , 57 ) and dry eyes ( 58 ) constrain HRQoL.…”

Section: Discussionmentioning

confidence: 99%

“…For example, it has been found that constipation affects HRQoL to a similar extent as severe chronic diseases, such as osteoarthritis, rheumatoid arthritis, allergies, and diabetes ( 22 ). HRQoL is reduced by 24% in adults over 65 years with orthostatic intolerance, compared to those without this symptom ( 23 ). Dry mouth due to xerostomia and hyposalivation explained 17% of the HRQoL variance in adults with a mean age of 85 years ( 24 ).…”

Section: Introductionmentioning

confidence: 99%

Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life

et al. 2021

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Background: Autonomic symptoms are common in older adults, and a large body of literature focusing on age-related diseases shows that autonomic symptoms in these diseases constrain Health-Related Quality of Life (HRQoL). To our best knowledge, the association between autonomic symptoms in older adults, independent of specific diseases, and HRQoL has not yet been assessed.Aim: To assess the frequency and the effect of autonomic symptoms in general, as well as orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor symptoms, on HRQoL in older adults.Methods: Cross-sectional data of the fourth visit of the Tübinger evaluation of Risk factors for Early detection of Neurodegeneration (TREND) study were included. Autonomic symptoms, as assessed with the Composite Autonomic Symptom Score 31 (COMPASS 31), were quantified and compared with HRQoL, as assessed with the EuroQol five-level version (EQ-5D-5L). Statistical analyses included Spearman's rank correlation and multiple linear regression analysis.Results: The analysis included 928 participants with a median of 68 years; 47% were women. Of those, 85% reported at least one autonomic symptom. Gastrointestinal and secretomotor symptoms were most common. The COMPASS 31 total score and all subdomains were significantly associated with reduced HRQoL. Among the subdomains, the strongest correlations with HRQoL were found for gastrointestinal and bladder symptoms. Overall, autonomic symptoms alone explained 20% of the variance of HRQoL; when depressive mood was added, the model explained 32%.Conclusion: Autonomic symptoms are associated with HRQoL and depressive symptoms in older adults.

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Orthostatic hypotension and health-related quality of life among community-living older people in Korea

Cited by 10 publications

References 49 publications

Effect of Nursing Interventions on the Severity of Orthostatic Hypotension among Older Adults Residing in Assisted Living Facilities

Effect of Nursing Interventions on the Severity of Orthostatic Hypotension among Older Adults Residing in Assisted Living Facilities

Effect of Acute Levodopa Up-Titration on Blood Pressure in Patients With Early Stage Parkinson’s Disease: Results of a Levodopa Challenge Test

Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life

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