Orthophenanthroline as accelerator of brain tissue oxygen consumption

Panimon, Frieda; Horwitt, M. K.; Gerard, R. W.

doi:10.1002/jcp.1030170103

Cited by 11 publications

(6 citation statements)

References 22 publications

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“…[Mn(l,10-phen)zl(CH3CO).4H,zO (8 [Cu(l,10-phen)(CH3CO2)2l.H20 (9) and [Zn(1,10-phen)(CH3CO2)21.2H20 (10) [Cu(l,10-phen)Cl2].H20 (12) and [Zn(l,10-phen)Cl2].H20 (13) were made in a similar manner to 11 using CuCI:.2H20 and ZnC12, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Insights Into the Mode of Action of the Anti‐Candida Activity of 1,10‐Phenanthroline and its Metal Chelates

McCann

Geraghty

Devereux³

et al. 2000

Metal-Based Drugs

101

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Metal complexes of malonie acid (metal Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Ag(I)) were prepared and only the Ag(I) complex inhibited the growth of Candida albicans. Malonate complexes incorporating the chelating 1,10-phenanthroline (1,10-phen) ligand showed a range of activities: good (Mn(II), Cu(lI), Ag(I)); moderate (Zn(II)); poor (Co(II), Ni(II)). Metal-free 1,10-phen and Ag(CH3CO2) were also highly active. The metal-free non-chelating ligands 1,7-phenanthroline and 4,7-phenanthroline were inactive and the Cu(II), Mn(II) and Zn(II) complexs of 1,7-phen displayed only marginal activity. Whereas the Cu(II) malonate/1,10-phen complex induces significant cellular oxidative stress the Zn(II) analogue does not.

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Section: Introductionmentioning

confidence: 99%

“…[Cu(l,7-phen)(CH3CO2)2].2H20 (15) 10 1) and total glutathione content (GSH + GSSG) was estimated spectrophotometrically (_ 412 nm) by comparison to the rate of reduction with known amounts of DTNB.…”

Section: Introductionmentioning

confidence: 99%

Insights Into the Mode of Action of the Anti‐Candida Activity of 1,10‐Phenanthroline and its Metal Chelates

McCann

Geraghty

Devereux³

et al. 2000

Metal-Based Drugs

101

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“…For school curricula (12,13), a distinction was made between relatively mild failures (the repetition of grades within primary school) and serious failures (placement in a class with a simplified curriculum). For IQ tests, a reasonably comparable metric was obtained by defining mild failure as scoring below 95 and serious failure as scoring below 85.…”

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confidence: 99%

Chronic Focal Epileptiform Discharges Induced by Injection of Iron Into Rat and Cat Cortex

Willmore

Sypert

Munson

et al. 1978

Science

276

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A single injection of 5 or 10 microliters of ferrous or ferric chloride into rat or cat sensorimotor cortex resulted in chronic recurrent focal paroxysmal electroencephalographic discharges as well as behavioral convulsions and electrical seizures. Recurrent focal epileptiform discharge caused by cortical injection of iron salts suggests that the development of human posttraumatic epilepsy may depend, in part, on the neurochemical alterations induced by the principal metallic ions found in whole blood.

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“…Wholesale evaluation of films containing various types of driers required an apparatus capable of recording drying times while unattended. The Gardner drying time recorder (8) was employed throughout this work. It consists of a Bakelite dolly 29 X 4 inches equipped, with casters at either end, and directed by a metal guide to progress horizontally at a rate of three centimeters per hour by means of a rack engagement to a synchronous motor.…”

Section: Equipmentmentioning

confidence: 99%

“…The criterion of drying, the so-called drop time, occurred when the thread of material breaking away from the departing tooth of the wheel had become sufficiently rigid to prevent a small drop from forming in the center of the impression. This criterion has been referred to as sefito-touch time in Gardner and Sward (8).…”

Section: Materials and Standardsmentioning

confidence: 99%