Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) study: blood management in elective knee and hip arthroplasty in Europe*

Rosencher, Nadia; Kerkkamp, H. E. M.; Macheras, George A.; Munuera, L.; Menichella, G; Barton, D. P. J.; Cremers, S; Abraham, Ivo; Investigation, For The OSTHEO

doi:10.1046/j.1537-2995.2003.00348.x

Cited by 540 publications

(464 citation statements)

References 25 publications

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“…26 Data were collected from 225 centres in France, Germany, Greece, Italy, the Netherlands, and Spain. Overall, 69% of patients received transfusion, including 35% who received autologous transfusions only and 25% who received allogeneic blood transfusions (ABTs) only.…”

Section: Transfusion and Preoperative Anaemiamentioning

confidence: 99%

Patient Blood Management in Europe

Shander¹,

Aken²,

Gombotz³

et al. 2013

Survey of Anesthesiology

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Section: Transfusion and Preoperative Anaemiamentioning

confidence: 99%

Patient Blood Management in Europe

Shander¹,

Aken²,

Gombotz³

et al. 2013

Survey of Anesthesiology

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“…However, most of the blood loss in TKA occurs in the immediate postoperative period [7,9,14]. Some authors state that this blood loss mainly originates from bone cuts uncovered by cement and implants [9,11,13].…”

Section: Introductionmentioning

confidence: 99%

Intraarticular Fibrinogen Does Not Reduce Blood Loss in TKA: A Randomized Clinical Trial

Heyse

Haas

Drinkwater

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background Bleeding remains an ongoing concern after total knee arthroplasty (TKA). Intraarticular application of human fibrinogen with a topical thrombin has been described to stop diffuse bleeding in knee arthroplasty. Questions/purposes It was hypothesized that the use of human fibrinogen as a topical agent would result in a reduction of bleeding and transfusions required after TKA; secondary end points included comparison of early clinical results including pain scores and range of motion (ROM) at 6 weeks and complications after surgery.

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“…The prevalence of BTs after total knee arthroplasty has been reported to be between 11% to 69%. [23,24] However, overall postoperative losses were significantly lower in patients with IV administration of TA (200 mL of blood less compared to group that did not receive TA). Also, the local means of TA administration was associated with lower overall losses, by 150 mL of blood.…”

Section: Discussionmentioning

confidence: 99%

Comparison of intravenous and intra-articular tranexamic acid in reducing blood loss in primary total knee replacement

Lacko¹

2017

Eklem Hastalik Cerrahisi

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ÖZAmaç: Bu çalışmada primer tek taraflı çimentolu total diz ameliyatı sırasında kan kaybını ve ameliyat sonrası erken komplikasyonların derecesini azaltmada intraartiküler traneksamik asit (TA) ve intravenöz (İV) TA'nın etkinliği ve güvenilirliği karşılaştırıldı. Hastalar ve yöntemler: Bu prospektif randomize çalışmaya diz osteoartriti olup tek taraflı çimentolu total diz replasmanı ameliyatı geçiren 90 hasta (36 erkek, 54 kadın; ort. yaş 68,7 yıl; dağılım 47-82 yıl) dahil edildi. Hastalar üç gruba randomize edildi: grup 1'e ameliyattan 20 dakika önce ve ilk dozdan üç saat sonra İV yolla TA (doz 10 mg/kg) verildi, grup 2'ye cerrahi alana lokal olarak (intraartiküler) TA (doz 3 g) verildi ve grup 3'e TA verilmedi. Ameliyat sırasındaki kan kaybı, ameliyat sonrası 24 saatte boşaltılan kan miktarı, toplam kan kaybı, hemoglobin ve hematokrit düzeylerindeki azalma ve kan transfüzyonu miktarı ölçüldü. Bulgular: Hastaların ameliyat öncesi demografik verilerinde gruplar arasında farklılık yoktu. Traneksamik asitin lokal veya İV uygulaması kan transfüzyonu sayısını ve drenajdaki kan kaybını anlamlı şekilde azalttı. Traneksamik asitin İV uygulaması istatistiksel olarak anlamlı daha yüksek hemoglobin ve hematokrit düzeyleri ve daha düşük ameliyat sonrası toplam kan kaybı ile ilişkiliydi. Grupların hiçbirinde ciddi komplikasyon gözlemlenmedi. Sonuç: Kan transfüzyonu sayısını azaltmada intraartiküler TA İV rejim kadar etkili idi. Ancak TA'nın İV uygulaması daha düşük toplam kan kaybı ile ilişkiliydi. Bulgularımız total diz replasmanı sırasında TA'nın İV uygulamasının intraartiküler uygulamaya göre daha üstün olduğunu gösterdi.Anahtar sözcükler: Artroplasti; diz; replasman; traneksamik asit. ABSTRACT Objectives:This study aims to compare the efficacy and safety of intra-articular tranexamic acid (TA) versus intravenous (IV) TA in the reduction of perioperative blood loss and the degree of early postoperative complications associated with primary unilateral cemented total knee replacement. Patients and methods: This prospective randomized study included 90 patients (36 males, 54 females; mean age 68.7 years; range 47 to 82 years) with knee osteoarthritis undergoing a unilateral cemented total knee replacement. Patients were randomized into three groups: group 1 received TA intravenously (dose 10 mg/kg) 20 minutes preoperatively and three hours after first dose, group 2 received TA (dose 3 g) locally (intra-articular) into surgical site, and group 3 did not receive TA. We measured perioperative blood loss, volume of drained blood in 24 hours postoperatively, overall blood loss, decrease in hemoglobin and hematocrit levels, and amount of blood transfusion. Results: There were no differences between the groups in terms of patient preoperative demographics. Local or IV administration of TA significantly reduced the number of blood transfusions and blood losses in drainage. Intravenous application of TA was associated with statistically significantly higher hemoglobin and hematocrit levels and lower overall postoperative blood losse...

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Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) study: blood management in elective knee and hip arthroplasty in Europe*

Abstract: Accurate assessment of preoperative Hb levels, better estimation of perioperative blood loss, efficient use of autologous blood, adherence to transfusion guidelines, and pharmacologic alternatives contribute to effective and comprehensive blood and anemia management.

Cited by 540 publications

References 25 publications

Patient Blood Management in Europe

Patient Blood Management in Europe

Intraarticular Fibrinogen Does Not Reduce Blood Loss in TKA: A Randomized Clinical Trial

Comparison of intravenous and intra-articular tranexamic acid in reducing blood loss in primary total knee replacement

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