Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review

Bădulescu, Oana Viola; Sîrbu, Paul Dan; Ungureanu, Carmen; Pînzariu, Alin Constantin; Cojocaru, Elena; Filip, Nina; Bararu-Bojan, Iris; Vladeanu, Maria; Ciocoiu, Manuela

doi:10.3892/etm.2021.10427

Cited by 11 publications

(8 citation statements)

References 37 publications

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“…For example, the ROADMAP-CAD study is a prospective study that seeks to evaluate the utility of measuring hypercoagulability biomarkers to better diagnose severe coronary artery disease. This research by Gerotziafas et al showed promising results indicating that hypercoagulability assessment could be proposed to screen patients with severe CAD [76][77][78]-Table 3. • the anticardiolipin and anti-beta-2 glycoprotein-1 antibodies (IgG and IgM isotypes) and lupus anticoagulant;…”

Section: Discussionmentioning

confidence: 99%

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

Bararu Bojan,

Dobreanu,

Vladeanu

et al. 2024

IJMS

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Cardiovascular diseases, among which includes coronary artery disease, represent one of the most important causes of mortality and morbidity worldwide. Research aimed at determining the risk factors involved recognizes a group of “traditional” risk factors, but also more recent studies identified over 100 “novel” ones which may have a role in the disease. Among the latter is the thrombophilia profile of a patient, a pathology well-established for its involvement in venous thromboembolism, but with less studied implications in arterial thrombosis. This paper reviews the literature, explaining the pathophysiology of the thrombophilia causes associated most with coronary thrombosis events. Results of several studies on the subject, including a meta-analysis with over 60,000 subjects, determined the significant involvement of factor V Leiden, prothrombin G20210A mutation, plasminogen activator inhibitor–1 and antiphospholipid syndrome in the development of coronary artery disease. The mechanisms involved are currently at different stages of research, with some already established and used as therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

Bararu Bojan,

Dobreanu,

Vladeanu

et al. 2024

IJMS

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“…In this regard, we demonstrated the fact that being in blood group 0, showing the presence of anemia and undergoing prolonged hospitalization in a NICU increased the rate of NI. Blood groups and hematologic disorders are frequent targets in epidemiological studies because they are genetically determined traits with known polymorphic expression among individuals and populations [ 27 , 28 ]. A recent meta-analysis confirms the increased susceptibility of patients of blood type 0 to viral infections [ 29 ], and another study demonstrated that the oral pathogen Candida albicans showed a significantly higher interaction with blood group-0 type buccal epithelial cells relative to other blood groups [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Nosocomial Infections Affecting Newborns with Abdominal Wall Defects

et al. 2023

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Abdominal wall defects are serious birth defects, with long periods of hospitalization and significant costs to the medical system. Nosocomial infection (NI) may be an additional risk factor that aggravates the evolution of newborns with such malformations. Methods: in order to analyze the factors that may lead to the occurrence of NI, we performed a retrospective study over a period of thirty-two years (1990–2021), in a tertiary children’s hospital; 302 neonates with omphalocele and gastroschisis were eligible for the study. Results: a total of 33.7 % patients were infected with one or more of species of bacteria or fungi. These species were Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp., Staphylococcus spp., Enterococcus spp. or Candida spp., but the rate of NI showed a significant decrease between the 1990–2010 and 2011–2021 period (p = 0.04). The increase in the number of surgeries was associated with the increase in the number of NI both for omphalocele and gastroschisis; in the case of gastroschisis, the age of over 6 h at the time of surgery increased the risk of infection (p = 0.052, marginal statistical significance). Additionally, for gastroschisis, the risk of NI was 4.56 times higher in the presence of anemia (p < 0.01) and 2.17 times higher for the patients developing acute renal failure (p = 0.02), and a hospitalization period longer than 14 days was found to increase the risk of NI 3.46-fold (p < 0.01); more than 4 days of TPN was found to increase the NI risk 2.37-fold (p = 0.015). Using a logistic regression model for patients with omphalocele, we found an increased risk of NI for those in blood group 0 (OR = 3.8, p = 0.02), in patients with a length of hospitalization (LH) of ≥14 days (OR = 6.7, p < 0.01) and in the presence of anemia (OR = 2.5, p = 0.04); all three independent variables in our model contributed 38.7% to the risk of NI. Conclusion: although in the past 32 years we have seen transformational improvements in the outcome of abdominal wall defects, there are still many factors that require special attention for corrections.

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“…Currently, the materials widely used in orthopedics are metal, bioceramics, and polymers [103][104][105][106][107][108][109][110]. Recent data suggest that a special interest is being given to biomedical nanotechnology.…”

Section: Future Perspectives For the Materials Used In Orthopedicsmentioning

confidence: 99%

Biomaterials in Orthopedic Devices: Current Issues and Future Perspectives

et al. 2022

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In orthopedics, bone fixation imposes the use of implants in almost all cases. Over time, the materials used for the implant have evolved from inert materials to those that mimic the morphology of the bone. Therefore, bioabsorbable, biocompatible, and bioactive materials have emerged. Our study aimed to review the main types of implant materials used in orthopedics and present their advantages and drawbacks. We have searched for the pros and cons of the various types of material in the literature from over the last twenty years. The studied data show that consecrated metal alloys, still widely used, can be successfully replaced by new types of polymers. The data from the literature show that, by manipulating their composition, the polymeric compounds can simulate the structure of the different layers of human bone, while preserving its mechanical characteristics. In addition, manipulation of the polymer composition can provide the initiation of desired cellular responses. Among the implanting materials, polyurethane is distinguished as the most versatile polymeric material for use both as orthopedic implants and as material for biomechanical testing of various bone reduction and fixation techniques.

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Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review

Cited by 11 publications

References 37 publications

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

Nosocomial Infections Affecting Newborns with Abdominal Wall Defects

Biomaterials in Orthopedic Devices: Current Issues and Future Perspectives

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