Orthopaedic Radiology

Brindle, Kathleen A.; Brindle, Tim

doi:10.1016/b978-0-323-28683-1.00036-9

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Chemiluminescence Detection1

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2019

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“…A sevenplex prototype assay using proprietary Q-plex technology was utilized to determine micronutrient deficiencies in pregnant women from Africa. 59 The system uses quantitative CL and simultaneously measures up to seven different analytes in a mixture. It uses a 96well plate format and requires a minimum 5 μL sample, which is diluted to 50 μL with the necessary reagents.…”

Section: Chemiluminescence Detectionmentioning

confidence: 99%

Multiplexed Immunosensors and Immunoarrays

et al. 2019

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Immunoassays make use of highly specific antigen-antibody binding and provide sensitive ways to detect a wide range of biomacromolecules, bacteria, viruses, and small molecules. There are a range of types of immunoassay systems including single analyte sensors, 96well plate formats, arrays, microfluidic sensors, microfluidic arrays, etc. A big target is encompassed by medical diagnostic biomarkers, which are "molecules that can be measured objectively as indicators of normal or disease processes and responses to therapeutic intervention". 1 Accurate, low-cost measurements of multiple proteins are major applications of immunoarrays that are critical for future early detection and monitoring of cancer and other diseases. Multiplexing is very important, since panels of biomarker proteins, as opposed to single biomarkers, are required to provide sufficient information content for reliable disease diagnostics.

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Section: Chemiluminescence Detectionmentioning

confidence: 99%