Orthokeratinized odontogenic cyst: a clinicopathological and immunocytochemical study of 15 cases

Abstract

These findings suggest that OOC is clinicopathologically separate from other types of odontogenic cysts and may thus constitute a distinct clinical entity.

Multiple Orthokeratinized Odontogenic Cysts: A Case Report

“…Based on these findings and the diagnostic criteria proposed by the First International Colloquium on NBCCS, this patient does not have NBCCS. The findings of this case report support the findings from previous case series regarding sporadic OOC cases [1][2][3][4] that OOC does not appear to be associated with NBCCS. …”

“…OOC shows a different clinical behavior from OKC and most authors have concluded that it is not associated with nevoid basal cell carcinoma syndrome (NBCCS) [1][2][3][4], in which multiple OKCs are one of the major features [5]. However, all the OOC cases reported to date were sporadic cases and each patient had a single OOC.…”

Odontogenic Keratocyst, Orthokeratinized Odontogenic Cyst and Epidermal Cyst: An Immunohistochemical Study Including Markers of Proliferation, Cytokeratin and Apoptosis Related Factors

“…Microscopically, OKC consists of a uniform epithelial lining with a well-developed basal cell layer and a corrugated parakeratinized surface (1,4). Recent studies have discussed the histologic variants (parakeratin vs. orthokeratin) ofOKC (3,(5)(6)(7)(8)(9). Microscopically, the majority of OKC are parakeratinized OKC and orthokeratinized OKCs are only 12.2% (5).…”

“…Microscopically, the majority of OKC are parakeratinized OKC and orthokeratinized OKCs are only 12.2% (5). In addition, some investigators described that orthokeratinized OKC had clincopathologically less recurrence rate as compare with parakeratinized OKC and therefore it should be placed into a different category (5,6,8). Moreover a few researchers designated orthokeratinized OKC as orthokeratinized odontogenic cyst (OOC) (1,8,9).…”

“…In addition, some investigators described that orthokeratinized OKC had clincopathologically less recurrence rate as compare with parakeratinized OKC and therefore it should be placed into a different category (5,6,8). Moreover a few researchers designated orthokeratinized OKC as orthokeratinized odontogenic cyst (OOC) (1,8,9). On the other hand, epidermal cyst (EDC) is a common cyst 14 of the skin that is lined by epidermis-like epithelium (1,2).…”