Orthohepevirus C hepatitis, an underdiagnosed disease?

Rodriguez, Christophe; Marchand, Sarah; Sessa, Anna; Cappy, Pierre; Pawlotsky, Jean‐Michel

doi:10.1016/j.jhep.2023.02.008

Cited by 20 publications

(29 citation statements)

References 10 publications

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“…The first detection of HEV‐C1 viral genome in humans was confirmed in plasma, feces, saliva, and liver tissue specimens from immunocompromised patients who underwent solid organ transplantation in Hong Kong in 2017 28 . Since the first human infection with HEV‐C1 was reported, 13 clinical cases have been documented and characterized based on clinical sequencing of patients in Hong Kong, Canada, Spain, and France 25–29 . Clinically, HEV‐C1 infection showed similar burdens of persistent hepatitis E among immunocompromised patients in Hong Kong compared to P. balayani infection 41 .…”

Section: Discussionmentioning

confidence: 94%

“…28 Since the first human infection with HEV-C1 was reported, 13 clinical cases have been documented and characterized based on clinical sequencing of patients in Hong Kong, Canada, Spain, and France. [25][26][27][28][29] Clinically, HEV-C1 infection showed similar burdens of persistent hepatitis E among immunocompromised patients in Hong Kong compared to P. balayani infection. 41 Although public health concerns regarding rat HEV infection have increased, active surveillance for the early discovery of HEV-C1 has not been conducted in wild rats in the ROK.…”

Section: Discussionmentioning

confidence: 95%

“…22 Serological evidence of HEV-C1 infection in humans was reported from Germany, Vietnam, Hong Kong, Spain, and France. [23][24][25][26][27] Chronic HEV-C1 infection was first confirmed in a liver transplant recipient in Hong Kong in 2018. 28 The presence of HEV-C1 RNA was detected in an immunocompetent patient with severe acute hepatitis who was presumably infected in Central Africa.…”

Section: Introductionmentioning

confidence: 99%

“…29 Hitherto, 13 clinical cases of HEV-C1 infection were documented from immunocompetent and immunocompromised patients in Hong Kong, Canada, Spain, and France. [25][26][27][28][29] Although public health concern of HEV-C1 infection has increased, rat HEV is still globally underestimated because of limited knowledge of the transmission route and mode, genome epidemiology, and zoonosis risk of these viruses. 30 In this study, an epidemiological survey was performed in wild rats to determine the molecular prevalence of HEV-C1 in the ROK between 2011 and 2021.…”

Section: Introductionmentioning

confidence: 99%

“…Serological evidence of HEV‐C1 infection in humans was reported from Germany, Vietnam, Hong Kong, Spain, and France 23–27 . Chronic HEV‐C1 infection was first confirmed in a liver transplant recipient in Hong Kong in 2018 28 .…”

Section: Introductionmentioning

confidence: 99%

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First detection and characterization of hepatitis E virus (Rocahepevirus ratti) from urban Norway rats (Rattus norvegicus) in the Republic of Korea

Park,

Kim,

Noh

et al. 2024

Journal of Medical Virology

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Hepatitis E virus (HEV), an emerging zoonotic pathogen, poses a significant public health concern worldwide. Recently, rat HEV (Rocahepevirus ratti genotype C1; HEV‐C1) has been reported to cause zoonotic infections and hepatitis in humans. Human infections with HEV‐C1 are considered to be underestimated worldwide due to limited knowledge of transmission routes, genome epidemiology, and the risk assessment of zoonosis associated with these viruses. A total of 186 wild Norway rats (Rattus norvegicus) were collected from the Republic of Korea (ROK) between 2011 and 2021. The prevalence of HEV‐C1 RNA was 8 of 180 (4.4%) by reverse‐transcription polymerase chain reaction. We first reported three nearly whole‐genome sequences of HEV‐C1 newly acquired from urban rats in the ROK. Phylogenetic analysis demonstrated that Korea‐indigenous HEV‐C1 formed an independent genetic group with those derived from R. norvegicus rats in other countries, indicating geographical and genetic diversity. Our findings provide critical insights into the molecular prevalence, genome epidemiology, and zoonotic potential of Rocahepevirus. This report raises awareness of the presence of Rocahepevirus‐related hepatitis E among physicians in the ROK.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

First detection and characterization of hepatitis E virus (Rocahepevirus ratti) from urban Norway rats (Rattus norvegicus) in the Republic of Korea

Park,

Kim,

Noh

et al. 2024

Journal of Medical Virology

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Detection of hepatitis E virus genotype 3 in an Algerian mouse (Mus spretus) in Portugal

Santos-Silva,

Moraes,

López-López

et al. 2024

Vet Res Commun

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Virus monitoring in small mammals is central to the design of epidemiological control strategies for rodent-borne zoonotic viruses. Synanthropic small mammals are versatile and may be potential carriers of several microbial agents. In the present work, a total of 330 fecal samples of small mammals were collected at two sites in the North of Portugal and screened for zoonotic hepatitis E virus (HEV, species Paslahepevirus balayani). Synanthropic small mammal samples (n = 40) were collected in a city park of Porto and belonged to the species Algerian mouse (Mus spretus) (n = 26) and to the greater white-toothed shrew (Crocidura russula) (n = 14). Furthermore, additional samples were collected in the Northeast region of Portugal and included Algerian mouse (n = 48), greater white-toothed shrew (n = 47), wood mouse (Apodemus sylvaticus) (n = 43), southwestern water vole (Arvicola sapidus) (n = 52), Cabrera’s vole (Microtus cabrerae) (n = 49) and Lusitanian pine vole (Microtus lusitanicus) (n = 51). A nested RT-PCR targeting a part of open reading frame (ORF) 2 region of the HEV genome was used followed by sequencing and phylogenetic analysis. HEV RNA was detected in one fecal sample (0.3%; 95% confidence interval, CI: 0.01–1.68) from a synanthropic Algerian mouse that was genotyped as HEV-3, subgenotype 3e. This is the first study reporting the detection of HEV-3 in a synanthropic rodent, the Algerian mouse. The identified HEV isolate is probably the outcome of either a spill-over infection from domestic pigs or wild boars, or the result of passive viral transit through the intestinal tract. This finding reinforces the importance in the surveillance of novel potential hosts for HEV with a particular emphasis on synanthropic animals.

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High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden

Churqui,

Ghaleb,

Tunovic

et al. 2024

One Health

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Orthohepevirus C hepatitis, an underdiagnosed disease?

Cited by 20 publications

References 10 publications

First detection and characterization of hepatitis E virus (Rocahepevirus ratti) from urban Norway rats (Rattus norvegicus) in the Republic of Korea

First detection and characterization of hepatitis E virus (Rocahepevirus ratti) from urban Norway rats (Rattus norvegicus) in the Republic of Korea

Detection of hepatitis E virus genotype 3 in an Algerian mouse (Mus spretus) in Portugal

High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden

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