Orthogonal Synthesis of Covalent Polydendrimer Frameworks by Fusing Classical and Onion-Peel Phosphorus-Based Dendritic Units

Abstract

We report novel and new giant three-dimensional polymers having dendrimers as repeating units. The approach is illustrated here for macromolecular synthesis by polymeric condensation of well-defined single phosphorus dendrimers units. Specifically, classical and onion-peel phosphorus dendrimers, constructed by a divergent method from a cyclotriphosphazene core, were fused within the same tectonic nanostructure by several polymeric condensation approaches including hydrazine-to-aldehyde Schiff-base formation and amine-to-carboxylic acid peptide-like coupling. These reticular, easy to run metal-free routes afford a new library of hyperbranched macromolecular materials, featuring various phosphorus layers (both alternated and dissymmetrical), well-defined textured nanospheres, and controllable nanometric ordered substructures. The scope of the concept is successfully expanded to the integration of electro-redox viologen units resulting in the synthesis of new photoactive macromolecular materials.

Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities

“…The anionic phosphorus dendrimer AN-G4 was synthesized in Laboratoire de Chimie de Coordination, CNRS, Toulouse, France. The anionic phosphorus dendrimer AN-G4 was prepared according to the method previously reported [59].…”

Phosphorus Science-Oriented Design and Synthesis of Multifunctional Nanomaterials for Biomedical Applications

“…Briefly, the phosphorus-containing dendrimers are fabricated based on the coordination chemistry. 51 After decades of development, various types of phosphorus-containing dendrimers were invented, including those with onion-peel dendritic structure, 52 those with Janus structure, 53 and water-soluble phosphorus dendrimers containing repeating phosphate units. 54,55 While other reviews have generally summarized the development of phosphorus-containing dendrimers systematically, 56,57 we mainly focus on water-soluble and degradable phosphorus-containing dendrimers, which have the most potential in biomedicine.…”

Phosphorhydrazones as Useful Building Blocks for Special Architectures: Macrocycles and Dendrimers

“…Star polymers based on phosphorhydrazone dendrimers were obtained by grafting poly(vinylidene fluoride) (PVDF) (Figure ); an increased crystallinity of PVDF when grafted was observed . Three‐dimensional polymers constituted of dendrimers as repeating units were obtained by hydrazine‐to‐aldehyde Schiff‐base formation (from aldehyde and hydrazine terminal functions of dendrimers) and amine‐to carboxylic acid peptide‐like coupling (from hydrazine and carboxylate terminal functions) …”