Orthogonal polarization technique in the assessment of human skin microcirculation

Lupi, Omar; Semenovitch, Ivan; Treu, Curt

doi:10.1111/j.1365-4632.2008.03694.x

Cited by 21 publications

(12 citation statements)

References 36 publications

(97 reference statements)

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“…A large part of the radiation is reflected through a polarizer oriented orthogonally to the plane of the light. Only a small amount of light is able to penetrate to deeper layers, where it undergoes multiple dispersion, depolarization, or reissues to the surface [114]. The degree of penetration of polarized light depends on the density of the examined object and the power of the polarized radiation used.…”

Section: Orthogonal Polarization Spectral Imagingmentioning

confidence: 99%

“…It is a handheld device that uses a polarized light technique to examine the absorption of haemoglobin [113]. OPS imaging allows for the in vivo assessment of the microcirculation up to a depth of 3 mm in the skin [114]. The tissue being investigated is illuminated with linearly polarized light at a wavelength of 538 nm.…”

Section: Orthogonal Polarization Spectral Imagingmentioning

confidence: 99%

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Microvascular dysfunction in diabetic foot disease and ulceration

Chao

Cheing

2009

Diabetes Metabolism Res

162

126

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Diabetic foot disease and ulceration is a major complication that may lead to the amputation of the lower limbs. Microangiopathy may play a significant role in the pathogenesis of tissue breakdown in the diabetic foot. However, the precise mechanisms of this process remain unclear and poorly understood. Microvasculature in the skin is comprised of nutritive capillaries and thermoregulatory arteriovenous shunt flow. It is regulated through the complex interaction of neurogenic and neurovascular control. The interplay among endothelial dysfunction, impaired nerve axon reflex activities, and microvascular regulation in the diabetic patient results in the poor healing of wounds. Skin microvasculature undergoes both morphologic changes as well as functional deficits when parts of the body come under stress or injury. Two important theories that have been put forward to explain the abnormalities that have been observed are the haemodynamic hypothesis and capillary steal syndrome. With advances in medical technology, microvasculature can now be measured quantitatively. This article reviews the development of microvascular dysfunction in the diabetic foot and discusses how it may relate to the pathogenesis of diabetic foot problems and ulceration. Common methods for measuring skin microcirculation are also discussed.

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Section: Orthogonal Polarization Spectral Imagingmentioning

confidence: 99%

Section: Orthogonal Polarization Spectral Imagingmentioning

confidence: 99%

Microvascular dysfunction in diabetic foot disease and ulceration

Chao

Cheing

2009

Diabetes Metabolism Res

162

126

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“…Other methods quantifying skin reaction after blanching pressure are available [19][20][21]32], some of which have been used previously in similar applications [23,26,33,34]. The advantage of TiVi is its correlation with RBC concentration whereas other devices focus more on the general colour change of skin, possibly making data more sensitive to each subjects skin colour.…”

Section: Limitationsmentioning

confidence: 99%

Reflectance spectroscopy: to shed new light on the capillary refill test

John

Henricson

Nilsson³

et al. 2017

Journal of Biophotonics

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To use Bioengineering methodology is used to achieve, at five anatomical sites, a detailed, quantitative assessment of the return of blood content to the blanched area, during the Capillary Refill (CR) test. An observational, non-randomized, experimental study on 23 healthy subjects (14 females) was performed in our climate controlled skin physiology laboratory. Our main outcome measures were based on the chronological assessment and quantification of red blood cell concentration (RBC) after the release of blanching pressure in the CR test, using Tissue Viability Imaging (TiVi), a digital photographic technique based on polarisation spectroscopy. TiVi enabled collection of detailed data on skin RBC concentration during the CR test. The results were shown as curves with skin blood concentration (TiVi-value) on the y-axis and the time on the x-axis. Quantitative CR responses showed site and temperature variability. We also suggest possible objective endpoint values from the capillary refill curve. Detailed data on skin RBC concentration during the CR test is easily obtained and allows objective determination of end points not possible to achieve by naked eye assessment. These findings have the potential to place the utility of the CR test in a clinical setting in a new light.

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“…Optical microscopy-derived techniques such as videocapillaroscopy, orthogonal polarization spectral imaging, and side-stream dark field imaging all provide in vivo observations of the capillaries (Cutolo et al, 2008, Lupi et al, 2008, Treu et al, 2011. Different laser Doppler techniques such as laser Doppler flowmetry, laser Doppler imaging, and laser speckle contrast imaging provide a measurement of skin perfusion (Roustit and Cracowski, 2012).…”

Section: Blood Flow Measurementsmentioning

confidence: 99%

Preventing pressure ulcers by assessment of the microcirculation in tissue exposed to pressure

Bergstrand¹

2014

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Orthogonal polarization technique in the assessment of human skin microcirculation

Abstract: The OPS technique is a very promising tool for dermatologists and researchers, especially in the study of vasculitis, chronic venous insufficiency, and skin tumors.

Cited by 21 publications

References 36 publications

Microvascular dysfunction in diabetic foot disease and ulceration

Microvascular dysfunction in diabetic foot disease and ulceration

Reflectance spectroscopy: to shed new light on the capillary refill test

Preventing pressure ulcers by assessment of the microcirculation in tissue exposed to pressure

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