“Orthogonal polarization spectral imaging”Eine neue klinische Methode für das Monitoring der Mikrozirkulation

Schiessler, C; Schaudig, Sieglinde; Harris, A. G.; Christ, F.

doi:10.1007/s00101-002-0341-6

Cited by 16 publications

(11 citation statements)

References 3 publications

(4 reference statements)

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“…Zur Beurteilung der Durchblutung kann als orientierender Parameter die Kapillarfüllungszeit durch Druck auf das Nagelbett an den Fingern herangezogen werden. Mit der Technik des "orthogonal polarization spectral imaging" (OPS-imaging) steht zwar mittlerweile ein Untersuchungsverfahren zur Verfü-gung, das mikrovaskuläre Veränderun-gen am Menschen für verschiedene Organe direkt sichtbar machen kann und darüber hinaus nichtinvasiv ist [51]. Als Parameter können Gefäßdurchmesser, Erythrozytengeschwindigkeit und funktionelle Kapillardichte quantifiziert werden.…”

Section: Zusammenfassungunclassified

Permissive Hypotension beim schweren Trauma

Kreimeier¹,

Lackner

Prückner³

et al. 2002

Der Anaesthesist

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Hemodynamic instability in the polytraumatized patient is a predominant feature and most commonly secondary to blood loss accompanying injury. In these patients restoration of intravascular volume attempting to achieve normal systemic pressure faces the risk of increasing blood loss and thereby potentially affecting mortality. Due to the lack of controlled clinical trials in this field, the growing evidence that "hypotensive resuscitation" results in improved long-term survival and improved neurologic outcome, mainly stems from experimental studies in animals. In patient care, several concepts exist for the reduction of blood loss in conjunction with systemic hypotension: these involve "deliberate hypotension" (synonym "controlled hypotension", used intraoperatively under conditions of normovolemia and stable hemodynamics), "delayed resuscitation" (where the hypotensive period is intentionally prolonged until operative intervention), and "permissive hypotension" (synonym "hypotensive resuscitation", where all kinds of therapy are commenced including fluid therapy, thereby increasing systemic pressure without, however, reaching normotension). In this review the concept of "permissive hypotension" is delineated on the basis of macro- and microcirculatory changes secondary to hypovolemia and low driving pressure, and potential indications as well as limitations for the care of the traumatized patient are discussed.

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Section: Zusammenfassungunclassified

Permissive Hypotension beim schweren Trauma

Kreimeier¹,

Lackner

Prückner³

et al. 2002

Der Anaesthesist

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“…LSCI has been applied successfully to evaluate microcirculation in Microvascular Research 97 (2015) [137][138][139][140][141][142][143][144][145][146] Abbreviations: aPTT,activated partial thromboplastin time; CLP,cecal ligation and puncture; EPCR, endothelial PC receptor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HR, heartrates; ICAM-1, intercellular adhesion molecule; i.p., injectedintraperitoneally;LPS, lipopolysaccharide; LSCI, laser speckle contrast imaging; MAP, mean arterial pressure; MPO, myeloperoxidase; PAI-1, plasminogen activator inhibitor-1; PT, prothrombin time; ROI, region of interest; RT-PCR, reverse transcription-PCR; RT-PCR, reverse transcription-PCR; TF, tissue factor; TM, thrombomodulin; TUNEL, terminal deoxyribonucleotidyltransferasemediated dUTP nick-end labeling; VCAM-1, vascular cell adhesion molecule. the skin, gastrointestinal mucosa, and brain cortex (Senarathna et al, 2013, (Schiessler et al, 2002, (Briers et al, 2013. LSCI has been used to monitor liver microcirculation during temporary occlusion of blood inflow (Sturesson et al, 2013a(Sturesson et al, , 2013b.…”

Section: Introductionmentioning

confidence: 99%

Laser speckle contrast imaging for measurement of hepatic microcirculation during the sepsis: A novel tool for early detection of microcirculation dysfunction

Ren

Zhou

et al. 2015

Microvascular Research

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“…The orthogonal polarization spectral (OPS) imaging technique allows real time assessment of the skin microcirculation up to 3 mm in depth [15,16,17,18,19] in vivo . This technique enables the evaluation of functional capillary density, capillary morphology, dermal papilla diameter, capillary bulk diameter and capillary diameter.…”

Section: Introductionmentioning

confidence: 99%

Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis

et al. 2017

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Leprosy is a chronic granulomatous infection of skin and peripheral nerves caused by Mycobacterium leprae and is considered the main infectious cause of disability worldwide. Despite the several studies regarding leprosy, little is known about its effects on microvascular structure and function in vivo. Thus, we have aimed to compare skin capillary structure and functional density, cutaneous vasomotion (spontaneous oscillations of arteriolar diameter), which ensures optimal blood flow distribution to skin capillaries) and cutaneous microvascular blood flow and reactivity between ten men with lepromatous leprosy (without any other comorbidity) and ten age- and gender-matched healthy controls. Orthogonal polarization spectral imaging was used to evaluate skin capillary morphology and functional density and laser Doppler flowmetry to evaluate blood flow, vasomotion and spectral analysis of flowmotion (oscillations of blood flow generated by vasomotion) and microvascular reactivity, in response to iontophoresis of acetylcholine and sodium nitroprusside. The contribution of different frequency components of flowmotion (endothelial, neurogenic, myogenic, respiratory and cardiac) was not statistically different between groups. However, endothelial-dependent and -independent vasodilatations elicited by acetylcholine and sodium nitroprusside iontophoresis, respectively, were significantly reduced in lepromatous leprosy patients compared to controls, characterizing the existence of microvascular dysfunction. These patients also presented a significant increase in the number of capillaries with morphological abnormalities and in the diameters of the dermal papilla and capillary bulk when compared to controls. Our results suggest that lepromatous leprosy causes severe microvascular dysfunction and significant alterations in capillary structure. These structural and functional changes are probably induced by exposure of the microvascular bed to chronic inflammation evoked by the Mycobacterium leprae.

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“Orthogonal polarization spectral imaging”Eine neue klinische Methode für das Monitoring der Mikrozirkulation

Cited by 16 publications

References 3 publications

Permissive Hypotension beim schweren Trauma

Permissive Hypotension beim schweren Trauma

Laser speckle contrast imaging for measurement of hepatic microcirculation during the sepsis: A novel tool for early detection of microcirculation dysfunction

Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis

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