Facial asymmetry may affect the patient’s smile and aesthetics. Its correction represents a great challenge for the dental surgeons. The complexity and multidisciplinary nature of such cases requires that any intervention be preceded by scientific and practical knowledge, as well as an accurate diagnosis. The aim of this paper is to report a clinical case, following the CARE guidelines (guidelines for case reporting). A 16 year-follow-up of an orthodontic-surgical retreatment of facial asymmetry and severe root resorption of an adult patient with facial asymmetry, with aesthetic, physiological and functional consequences, is reported in this paper. The results showed correction of the facial asymmetry, with functional occlusal plane, molars and canines relations and dental and facial midlines. Also satisfactory aesthetic results were achieved. Functionally, the patient presented normal mandibular movements, in addition to the harmonious facial profile which improved lip sealing. After 16 years of orthodontic-surgical retreatment, the patient is still undergoing clinical and radiographic follow-up, which demonstrates the stability of the results; root resorption remained stable and there was regression of temporomandibular dysfunction (TMD) due to the improved occlusal function.