Background: Orthodontic treatment takes a long time in bone remodeling. Stichopus hermanii has various compounds such as EPA-DHA, calcium, Magnesium, Flavonoid and Triterpenoid, that K1, K2, K3, K4, P1, P2, P3, and P4 are (3,33 ± 1,211), (10,67 ± 1,211), (8,33 ± 0,816), (4,33 ± 1,211), (3 ± 0,894), (14,3 ± 1,633), (9,33 ± 1,366), and (12,67 ± 2,338