Orthobiologics in orthopedic applications: a report from the TMI Havemeyer meeting on orthobiologics

Lattermann, Christian; Leite, Chilan Bou Ghosson; Frisbie, David D.; Schlegel, Theodore S.; Bramlage, L. R.; Koch, Thomas; Centeno, Christopher J.; Goodrich, Laurie R.; Johnstone, Brian; Trumper, Rocci; Watts, Ashlee E.; Little, C.B.; Barry, Frank; Guilak, Farsh; McIlwraith, C. Wayne

doi:10.1016/j.jcjp.2022.100055

Cited by 1 publication

(3 citation statements)

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“…These have come from scientists and clinicians alike, who desire to translate these biologics into evidence-based medicine [70] [71]. In 2013, the International Cellular Medical Society asserted that there needs to be a standard Open Journal of Regenerative Medicine for PRP preparation, technical use, and outcome tracking [72] [73] [74]. In 2016, the 21st Century Cures Act was passed, which supported and encouraged development in the realm of regenerative medicine [71].…”

Section: A Push For Standardizationmentioning

confidence: 99%

“…In 2016, the 21st Century Cures Act was passed, which supported and encouraged development in the realm of regenerative medicine [71]. Advances in several basic science areas, such as cell biology, genomics, and biomaterials are leading to improved understanding of tissue degeneration, repair, and regeneration [74].…”

Section: A Push For Standardizationmentioning

confidence: 99%

“…".... biological substances found naturally in the body that help injuries heal more quickly." [74].…”

Section: An Updated Definitionmentioning

confidence: 99%

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Orthobiologics: An Updated Definition

Sutton¹,

Muran²,

Zaslav³

et al. 2023

OJRM

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Orthobiologics is a subset of regenerative medicine, which focuses on treating the musculoskeletal system. The main therapeutics utilized include plateletrich plasma, stem cells, exosomes, and scaffolding matrices. Continuous discoveries and new innovations have led to an increase in both popularity and usage of these therapeutics by various medical and scientific communities. Despite its potential, however, the field is viewed with significant skepticism secondary to poor documentation, a lack of standardization, vague nomenclature, disorganized research protocols, and an absence of a clear understanding of the mechanisms underlying the effects of the various therapeutics. This ambiguity led to a surge in direct-to-consumer marketing by "Stem Cell Clinics", putting patient's health at risk and further delegitimizing the field. These shortcomings led to a recent push for standardization by both professionals and organizations alike; a move that has put Orthobiologics on the path toward becoming a guideline-driven, protocol-based, and researchbacked specialty. And with these rapid changes comes the need for an updated definition of "Orthobiologics", a crucial element of any legitimate and standardized medical field.

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Section: A Push For Standardizationmentioning

confidence: 99%

Section: A Push For Standardizationmentioning

confidence: 99%