Orthobiologics

West, Tenaya A.; Williams, Mitzi L.

doi:10.1016/j.cpm.2019.06.006

Cited by 10 publications

(4 citation statements)

References 119 publications

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“…Orthobiologic compounds are a therapeutic class of biological substances proposed to augment the natural healing response by potentiating the body's innate restorative mechanisms 1 . They have received much interest in recent literature for use as an adjunct to both conservative and surgical treatment options in orthopaedic surgery.…”

mentioning

confidence: 99%

Efficacy of Platelet-Rich Plasma in Soft Tissue Foot and Ankle Pathology

et al. 2022

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The preparation methodology for platelet-rich plasma (PRP) may have important clinical implications with varying effectiveness with leukocyte, platelet, and growth factor concentrations.There is high-quality evidence to support the superiority of PRP over corticosteroids in the case of chronic plantar fasciitis.There is moderate-quality to high-quality evidence for PRP's ability to increase tendon thickness with no capacity to decrease pain, increase function, or augment percutaneous tenotomy in Achilles tendinopathy.There is insufficient evidence to support PRP injections in the definitive treatment of Achilles tendon rupture. However, PRP may contribute to postoperative recovery after tendon rupture repair, but this requires further research.The biochemical theory supporting the clinical use of PRP must be reinforced with high-level evidence research. Based on the current literature, PRP may serve as a viable treatment method in chronic plantar fasciitis. Further high-quality, comparative studies with longer clinical follow-up are required to support recommendations for use of PRP in the treatment of Achilles tendon pathology.

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confidence: 99%

Efficacy of Platelet-Rich Plasma in Soft Tissue Foot and Ankle Pathology

et al. 2022

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“…Osteochondral allograft transplantation with a graft from a donor avoids the potential complications from the donor site and allows larger grafts to be transplanted; however, limitations include donor accessibility, timing issues, risk of disease transmission, high costs, post-operative cyst formation, not to mention a technically demanding procedure [3,26]. Particulated juvenile cartilage allograft (PJCA) involves transplantation of cartilage from juvenile donors that contains chondrocytes with a higher potential to produce hyaline-like cartilage [27]. Extracellular matrix cartilage allograft (EMCA) consists of a cartilage matrix with various growth factors that can facilitate the differentiation of MSCs to chondrocytes [27].…”

Section: Bone and Cartilage Graftsmentioning

confidence: 99%

“…Particulated juvenile cartilage allograft (PJCA) involves transplantation of cartilage from juvenile donors that contains chondrocytes with a higher potential to produce hyaline-like cartilage [27]. Extracellular matrix cartilage allograft (EMCA) consists of a cartilage matrix with various growth factors that can facilitate the differentiation of MSCs to chondrocytes [27]. EMCA has been used as an adjunct to microfracture.…”

Section: Bone and Cartilage Graftsmentioning

confidence: 99%

Frontiers in Orthobiologics for the Treatment of Osteochondral Lesions of the Ankle Joint

Stake

Fukase

Ravuri

et al. 2020

OSMOAJ

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Volume 4 -Issue 3Copyrights @ Johnny Huard, et al. Orthop & Spo Med Op Acc J 399 has been preferred for larger lesions [3,5]. Unfortunately, the repair tissue, particularly in microfracture treatment, is primarily composed of fibrocartilage, which is less biomechanically robust than hyaline cartilage, and is more likely to degenerate over time.The aim of this review is to summarize the current literature on orthobiologics for treatment of OCLs of the ankle joint. We have focused on the biological adjuncts, including HA, PRP, and BMAC, with their benefits and limitations based on the latest evidence.Future directions for orthobiologics to promote cartilage repair are also discussed.

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“…Orthobiologics is an emerging field exploring augments to standards of care and new treatment modalities for orthopedic surgeries [ 1 , 2 , 3 , 4 , 5 , 6 ]. A new biologic modality uses point-of-care devices to convert a small quantity of whole blood into autologous activated serum (AAS) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Activated Serum Increases In Vitro Cellular Proliferation and Growth Factor Expression of Musculoskeletal Cells

Karsmarski

Hawthorne

Cusano

et al. 2022

JCM

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The purpose of this study was to investigate proteomic alteration that occurs to whole blood when converted to activated serum (AS) using an autologous thrombin system. This study further sought to evaluate the functional in vitro effect of AS on tenocytes, chondrocytes, subacromial bursal cells, and osteoblasts. The peptide/protein composition of AS was analyzed by liquid chromatography–mass spectrophotometry (LC-MS). The cell lines were treated with AS, and cellular proliferation was quantified 48 h after treatment. Platelet-derived growth factor (PDGF), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), interleukin-1 beta (IL-1β), and interleukin-1 receptor antagonist (IL-1Ra) were quantified utilizing enzyme-linked immunosorbent assays (ELISAs). LC-MS identified 357 proteins across the AS and whole blood. Fifty-four of the proteins identified had significant differences between the relative protein abundance of the AS samples compared to whole blood. Treatment with AS in all cell lines significantly increased proliferation compared to control cells at 48 h. Increased PDGF, VEGF, and IGF-1 in all cell lines exposed to AS compared to the control (p < 0.05) were observed. These findings suggest that treatment with AS increases in vitro cellular proliferation and the release of growth factors that may play a role in tissue repair.

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Orthobiologics

Cited by 10 publications

References 119 publications

Efficacy of Platelet-Rich Plasma in Soft Tissue Foot and Ankle Pathology

Efficacy of Platelet-Rich Plasma in Soft Tissue Foot and Ankle Pathology

Frontiers in Orthobiologics for the Treatment of Osteochondral Lesions of the Ankle Joint

Activated Serum Increases In Vitro Cellular Proliferation and Growth Factor Expression of Musculoskeletal Cells

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