Orthobiologic injections for treating degenerative meniscus lesions: a matter of facts? Ten years of clinical experience in a systematic review

Conte, Pietro; Anzillotti, Giuseppe; Matteo, Berardo Di; Gallese, Alessandro; Vitale, Umberto; Marcacci, Maurilio; Kon, Elizaveta

doi:10.1016/j.jcjp.2023.100104

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…For decades, intra‐articular HA therapies have been termed viscosupplements with the idea that they apparently restore the viscosity to injured SF 21,22 . Despite many clinical studies and meta‐analyses, the relationship between measured viscosity of HA and clinical outcomes is unclear 23–25 due to the low half‐life of exogenous HA in the joint. Notably, for these studies, the viscosities of these HAs were determined via conventional rheometry, in which lubricants are in contact with stiff impermeable materials such as glass or stainless steel, that have vastly different surface chemistries than cartilage.…”

Section: Introductionmentioning

confidence: 99%

Loss of effective lubricating viscosity is the primary mechanical marker of joint inflammation in equine synovitis

Vishwanath,

Secor,

Watkins

et al. 2024

Journal Orthopaedic Research

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Inflammation of the synovium, known as synovitis, plays an important role in the pathogenesis of osteoarthritis (OA). Synovitis involves the release of a wide variety of pro‐inflammatory mediators in synovial fluid (SF) that damage the articular cartilage extracellular matrix and induce death and apoptosis in chondrocytes. The composition of synovial fluid is dramatically altered by inflammation in OA, with changes to both hyaluronic acid and lubricin, the primary lubricating molecules in SF. However, the relationship between key biochemical markers of joint inflammation and mechanical function of SF is not well understood. Here, we demonstrate the application of a novel analytical framework to measure the effective viscosity for SF lubrication of cartilage, which is distinct from conventional rheological viscosity. Notably, in a well‐established equine model of synovitis, this effective lubricating viscosity decreased by up to 10,000‐fold for synovitis SF compared to a ~4 fold change in conventional viscosity measurements. Further, the effective lubricating viscosity was strongly inversely correlated (r = −0.6 to −0.8) to multiple established biochemical markers of SF inflammation, including white blood cell count, prostaglandin E2 (PGE2), and chemokine ligand (CCLs) concentrations, while conventional measurements of viscosity were poorly correlated to these markers. These findings demonstrate the importance of experimental and analytical approaches to characterize functional lubricating properties of synovial fluid and their relationships to soluble biomarkers to better understand the progression of OA.

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Section: Introductionmentioning

confidence: 99%