Ortho Esters, Imidic Esters and Amidines. IV. The Mechanism of the Reaction of Aniline with Ethyl Orthoformate¹

Cerium (IV) Ammonium Nitrate (CAN) Mediated Reactions IV. A Highly Efficient Synthesis of N,N’-Diarylsubstituted Formamidines in Water at Ambient Temperature

“…The resulting solid was collected by filtration and recrystallized from ethanol to afford analytically pure samples 3a-h. Compounds 3a-f have been described previously [31][32][33][34][35][36][37] and were found identical with our samples synthesized by our protocol.…”

Catalyst-Free Synthesis of Aryl Diamines via a Three-Step Reaction Process

“…In the first step, formamidine is prepared using substituted anilines with triethyl orthoformate; a similar procedure is used in previous reports but with different aniline substrates (Scheme a). , For the synthesis of symmetrical formamidines, the aniline derivatives (2 equiv) are mixed together with other reactants at the beginning of the reaction; however, for the synthesis of the unsymmetrical formamidine the two-different substituted anilines are added to the reaction mixture at different stages to avoid the formation of any symmetrical analogues (cross-products) that might result from side reactions. Accordingly, at the beginning of the reaction only the first substituted aniline (1 equiv) is added and allowed to reach its complete conversion to N -(Ethoxymethylene) aniline derivative . Then, the second substituted aniline (1 equiv) is added, and the reaction is continued under the same conditions.…”

Introduction of Two New Brønsted Acidic Ionic Liquids for the Formamide and Formamidine Derivatization of Amines

“…Although a variety of catalysts have been reported for the synthesis of formamidines and N, N'-diaryl formamidines, some of them suffer from disadvantages such as low yields, long reaction times, non-reusability of the catalyst and etc. Because of using toxic, metal-containing catalysts or expensive, heterogeneous ones [27][28][29][30] cause to utilize non-toxic, cost-saving ILs be more important. So, introduction of more effective methods and catalysts for the synthesis of these compounds is still of great importance.…”