Orphanin FQ-ORL-1 Regulation of Reproduction and Reproductive Behavior in the Female

Sinchak, Kevin; Dalhousay, Lauren; Sanathara, Nayna

doi:10.1016/bs.vh.2014.11.002

Cited by 7 publications

(7 citation statements)

References 169 publications

(279 reference statements)

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“…However, recent investigations in the spinal cord trigeminal neurons and hypothalamus (a unique brain region, which regulates the synthesis of sex steroids) suggest that the progesterone to estrogen ratio, which fluctuates during the menstrual cycle influences NOP receptor expression and binding. These studies have reported increases in NOP in the hypothalamic nuclei following both estrogen and estrogen + progesterone treatment; and decreases in NOP in the trigeminal neurons during the proestrous (high estrogen/low progesterone) compared to diestrous (low estrogen/high progesterone) phase of the rodent menstrual cycle (57,58). It is unclear as to whether, and how menstrual cycle phase may have influenced [ 11 C]NOP-1A V T measurements in the midbrain and cerebellum in this imaging study.…”

Section: Discussionmentioning

confidence: 99%

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder

Narendran

Tollefson

Fasenmyer

et al. 2019

Biological Psychiatry

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Post-traumatic stress disorder (PTSD) is a stress disorder that develops in only some individuals following a traumatic event. Data suggest that a substantial fraction of women recover after sexual violence. Thus, the investigation of stress and anti-stress neuropeptides in this sample has the potential to inform the neurochemistry of resilience following trauma. Nociceptin is an anti-stress neuropeptide in the brain that promotes resilience in animal models of PTSD. METHODS: [ 11 C]NOP-1A PET was used to measure the in vivo binding to nociceptin receptors in 18 college women who had experienced sexual violence irrespective of whether they met DSM-5 diagnostic criteria for PTSD. [ 11 C]NOP-1A data from 18 healthy controls was also included to provide a contrast with the sexual violence group. [ 11 C]NOP-1A total distribution volume (V T) in the regions of interest were measured with kinetic analysis using the arterial input function. The relationships between regional V T and Clinician-Administered PTSD Scale total symptom and subscale severity were examined using correlational analyses. RESULTS: No differences in [ 11 C]NOP-1A V T were noted between the sexual violence and control groups. V T in the midbrain and cerebellum were positively correlated with PTSD total symptom severity in the past month prior to PET. Intrusion/re-experiencing and avoidance subscale symptoms drove this relationship. Stratification of subjects by a DSM-5 PTSD diagnosis and contrasting their V T with that in controls showed no group differences. CONCLUSION: Decreased midbrain and cerebellum nociceptin receptors are associated with less severe PTSD symptoms. Medications that target nociceptin should be explored to prevent and treat PTSD.

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Section: Discussionmentioning

confidence: 99%

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder

Narendran

Tollefson

Fasenmyer

et al. 2019

Biological Psychiatry

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“…What this theory hypothesis does not explain is how estrogens alone induce lordosis, which required higher estrogen doses and a longer interval between estrogen treatment and the behavior (Pfaff, 1970 reviewed in Clemens and Weaver, 1985). What has emerged is the idea that different behavioral circuits are activated by estradiol only treatment compared with estrogen and progesterone (reviewed in Sinchak et al, 2015). In the ARH, estradiol-only facilitation of lordosis reflex requires the activation of the opioid receptor, ORL-1, but estradiol + progesterone does not (Borgquist et al, 2014).…”

Section: Steroid Activation Of Sexual Receptivitymentioning

confidence: 99%

“…Throughout the estrous cycle, the pattern of MPN MOR activation/internalization tracks the sexual receptivity of the female, that is, MOR are deactivated (internalized) on the evening of proestrus when the rat is sexually receptive and reactivated on the morning of estrus when she is no longer receptive (Sinchak and Micevych, 2003; reviewed in Micevych and Sinchak, 2013; Sinchak et al, 2015). …”

Section: Steroid Activation Of Sexual Receptivitymentioning

confidence: 99%

Integrating Neural Circuits Controlling Female Sexual Behavior

Micevych

Meisel

2017

Front. Syst. Neurosci.

112

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The hypothalamus is most often associated with innate behaviors such as is hunger, thirst and sex. While the expression of these behaviors important for survival of the individual or the species is nested within the hypothalamus, the desire (i.e., motivation) for them is centered within the mesolimbic reward circuitry. In this review, we will use female sexual behavior as a model to examine the interaction of these circuits. We will examine the evidence for a hypothalamic circuit that regulates consummatory aspects of reproductive behavior, i.e., lordosis behavior, a measure of sexual receptivity that involves estradiol membrane-initiated signaling in the arcuate nucleus (ARH), activating β-endorphin projections to the medial preoptic nucleus (MPN), which in turn modulate ventromedial hypothalamic nucleus (VMH) activity—the common output from the hypothalamus. Estradiol modulates not only a series of neuropeptides, transmitters and receptors but induces dendritic spines that are for estrogenic induction of lordosis behavior. Simultaneously, in the nucleus accumbens of the mesolimbic system, the mating experience produces long term changes in dopamine signaling and structure. Sexual experience sensitizes the response of nucleus accumbens neurons to dopamine signaling through the induction of a long lasting early immediate gene. While estrogen alone increases spines in the ARH, sexual experience increases dendritic spine density in the nucleus accumbens. These two circuits appear to converge onto the medial preoptic area where there is a reciprocal influence of motivational circuits on consummatory behavior and vice versa. While it has not been formally demonstrated in the human, such circuitry is generally highly conserved and thus, understanding the anatomy, neurochemistry and physiology can provide useful insight into the motivation for sexual behavior and other innate behaviors in humans.

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“…Thus far, all steroid paradigms studied regulate the output of ARH β-end neurons in a manner that is congruent with the rat’s sexual behavioral state [9, 47, 48, 59, 60, 84, 90, 93, 101–105]. Importantly, the association of behavior and MPN MOR activity is observed in intact cycling rats [95].…”

Section: Membrane Estrogen Receptors Regulating Sexual Receptivitymentioning

confidence: 99%

Estradiol Membrane-Initiated Signaling in the Brain Mediates Reproduction

Micevych

Mermelstein

Sinchak

2017

Trends in Neurosciences

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Over the past few years, our understanding of estrogen signaling in the brain has expanded rapidly. Estrogens are synthesized in the periphery and in the brain, acting on multiple receptors to regulate gene transcription, neural function, and behavior. Various estrogen-sensitive signaling pathways often work in concert within the same cell, increasing the complexity of the system. In females, estrogen concentrations fluctuate over the estrous/menstrual cycle, dynamically modulating estrogen receptor expression, activity and trafficking. These dynamic changes influence multiple behaviors, but are particularly important for reproduction. Using the female rodent model, we review our current understanding of estradiol signaling in the regulation of sexual receptivity.

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Orphanin FQ-ORL-1 Regulation of Reproduction and Reproductive Behavior in the Female

Cited by 7 publications

References 169 publications

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder

Integrating Neural Circuits Controlling Female Sexual Behavior

Estradiol Membrane-Initiated Signaling in the Brain Mediates Reproduction

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