Orphan Nuclear Receptor Rev-erb Alpha Gene &lt;i&gt;(NR1D1)&lt;/i&gt; and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population

Kishi, Taro; Kitajima, Tsuyoshi; Ikeda, Masashi; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Koichiro; Okochi, Tomo; Ozaki, Norio; Iwata, Nakao

doi:10.1159/000226612

Cited by 12 publications

(6 citation statements)

References 42 publications

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“…Two recent studies report nominal significant associations of genetic variation in NR1D1 in BD (Kishi et al, 2008;Severino et al, 2009) that are not replicated in our BD subset of patients, but conversely we found a positive nominal association in our MDD subsample, suggesting the possible involvement of NR1D1 in other MD-related phenotypes. However, NR1D1 gene does not seem to have a major role in the antidepressant response in MDD (Kishi et al, 2009c), despite its key role in circadian rhythm regulation. These findings deserve further investigation in larger samples considering homogeneous clinical phenotypes and circadian subphenotypes.…”

Section: Discussionmentioning

confidence: 95%

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

Soria

Martínez‐Amorós

Escaramís

et al. 2010

Neuropsychopharmacol

312

203

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Disruptions in circadian rhythms have been described in mood disorders (MD), but the involvement of genetic variation in genes pertaining to the molecular circadian machinery in the susceptibility to MD has not been conclusively determined. We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls. Nominally, statistically significant associations were found in 15 circadian genes. The gene-wide test, corrected for the number of SNPs analyzed in each gene, identified significant associations in CRY1 (rs2287161), NPAS2 (rs11123857), and VIPR2 (rs885861) genes with the combined MD sample. In the MDD subsample, the same SNPs in CRY1 and NPAS2 of the combined sample remained associated, whereas in the BD subsample CLOCK (rs10462028) and VIP (rs17083008) were specifically associated. The association with an SNP located 3 0 near CRY1 gene in MDD remained statistically significant after permutation correction at experiment level (p ¼ 0.007). Significant additive effects were found between the SNPs that were statistically significant at the gene-wide level. We also found evidence of associations between two-marker haplotypes in CRY1 and NPAS2 genes and MD. Our data support the contribution of the circadian system to the genetic susceptibility to MD and suggest that different circadian genes may have specific effects on MD polarity.

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Section: Discussionmentioning

confidence: 95%

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

Soria

Martínez‐Amorós

Escaramís

et al. 2010

Neuropsychopharmacol

312

203

View full text Add to dashboard Cite

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“…Recently, we reported that NR1D1 was not associated with major depressive disorder and selective serotonin reuptake inhibitor response to major depressive disorder [7, 22]. On the other hand, we detected the associations between PROKR2 and not only mood disorders including major depressive disorder and bipolar disorder but also METH dependence and METH-induced psychosis in the Japanese population [12, 23].…”

Section: Discussionmentioning

confidence: 77%

“…The evidence for this relation is discussed in more detail in our previous papers and a review by Barnard and Nolan [4-7]. …”

Section: Introductionmentioning

confidence: 99%

Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence

Kishi¹,

Kitajima²,

Kawashima³

et al. 2011

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Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3 β (GSK-3β) were shown to be important circadian components. In addition, the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between NR1D1 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with three tagging SNPs selected by HapMap database. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between NR1D1 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that NR1D1 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.

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“…A recent study has showed an association between common diseases such as schizophrenia and rare variants. If the genetic background of METH-induced psychosis is accurately described by the common disease-rare variants hypothesis, further investigation such as medical resequencing using larger samples will be required [8, 12-17]. …”

Section: Discussionmentioning

confidence: 99%

No Association Between GRM3 and Japanese Methamphetamine- Induced Psychosis

Tsunoka¹,

Kishi²,

Ikeda³

et al. 2011

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Several investigations have suggested that abnormalities in glutamate neural transmission play a role in the pathophysiology of psychiatric disorders, including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was reported to be associated with schizophrenia, and paranoid type schizophrenia has symptoms that are similar to those of methamphetamine-induced psychosis. This suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of methamphetamine-induced psychosis. To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls). Methods:We selected one functional SNP (rs6465084), reported to be associated with prefrontal brain functioning, for an association analysis. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA).Results:We did not detect an association between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis.Conclusion:Our findings suggest that rs6465084 in GRM3 does not play a major role in the pathophysiology of methamphetamine-induced psychosis in the Japanese population. However, because we did not perform an association analysis based on linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using a larger sample and based on LD may be required for conclusive results.

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Orphan Nuclear Receptor Rev-erb Alpha Gene <i>(NR1D1)</i> and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population

Cited by 12 publications

References 42 publications

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese Methamphetamine Dependence

No Association Between GRM3 and Japanese Methamphetamine- Induced Psychosis

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