Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice

Kim, Dong Hyun; Lee, Younghwan; Lee, Hyung Eun; Park, Se Jin; Jeon, Su Jin; Jeon, Se Jin; Cheong, Jae Hoon; Shin, Chan Young; Son, Kun Ho; Ryu, Jong Hoon

doi:10.1016/j.brainresbull.2014.09.001

Cited by 24 publications

(17 citation statements)

References 56 publications

(71 reference statements)

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“…In the present study, we also demonstrated that a bilateral IGF2 injection into the dorsal hippocampus 6 or 9 h after the acquisition trial of inhibitory avoidance task increased the step-through latency time in the retention trial, which was performed 24 h after the training. However, 12 h post-training IGF2 infusion had no effect on the step-through latencies compared with the vehicle-treated control group, which was similar to our previous mBDNF studies (Kim et al, 2012(Kim et al, , 2014Kwon et al, 2014). Thus, these findings indicate that exogenous IGF2 within 9 h after training enhances memory consolidation, and IGF2 is also a crucial factor for memory consolidation, as suggested by mBDNF.…”

Section: Discussionsupporting

confidence: 90%

“…However, at 9-12 h post-training, a protein synthesis inhibitor had no effect on memory formation (Bekinschtein et al, 2007;Kim et al, 2012). Additionally, it was reported that hippocampal mBDNF expression levels in the hippocampus 9 h after the acquisition trial is critically involved in the enhancement of memory consolidation (Kim et al, 2012(Kim et al, , 2014Kwon et al, 2014). However, the hippocampal mBDNF expression levels in a late consolidation phase, approximately 12 h after the initial learning, regulate memory persistence, not formation (Bekinschtein et al, 2007(Bekinschtein et al, , 2008.…”

Section: Discussionmentioning

confidence: 93%

“…Testing was conducted in identical (20 Â 20 Â 20 cm 3 ) illuminated and non-illuminated boxes, which were separated by a 5 Â 5 cm 2 guillotine door, as previously described (Kim et al, 2014). The illuminated compartment contained a 50 W bulb, and the floor of the non-illuminated compartment was composed of 2 mm stainless steel rods spaced 1 cm apart.…”

Section: 4mentioning

confidence: 99%

“…It has previously been reported that the inhibition of de novo protein synthesis with anisomysin or cycloheximide in the hippocampus approximately 3-6 h after the initial acquisition impaired memory consolidation, whereas it did not induce impairments 12 h after the acquisition trial (Bekinschtein et al, 2007;Kim et al, 2012). We recently reported that mature brain-derived neurotrophic factor (mBDNF) in the hippocampus enhances memory consolidation within 9 h after initial learning (Kim et al, 2012(Kim et al, , 2014Kwon et al, 2014). Furthermore, several lines of evidence have demonstrated that a late consolidation phase, approximately 12 h after initial learning, is required for the persistence of LTM.…”

Section: Introductionmentioning

confidence: 97%

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Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner

Lee

Gao

et al. 2015

Brain Research

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 93%

Section: 4mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner

Lee

Gao

et al. 2015

Brain Research

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“…BDNF is an important molecule that is necessary for the consolidation of short-term memory to long-term memory and for synaptic plasticity in the hippocampus. [47][48][49] According to our results, the expression levels of BDNF were increased in response to the administration of bee pollen extract in the hippocampus. Therefore, the cognitive-ameliorating effects of bee pollen might be associated in part with the increase in BDNF expression levels.…”

Section: Discussionmentioning

confidence: 55%

The Ameliorating Effects of Bee Pollen on Scopolamine-Induced Cognitive Impairment in Mice

Liao

Bae

Zhang

et al. 2019

Biological & Pharmaceutical Bulletin

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Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. However, its function in cognition has yet been investigated. In the present study, we investigated the ameliorating effect of bee pollen against scopolamine-caused cognitive impairment through the passive avoidance test, the Y-maze test and the Morris water maze test. In addition, Western blotting was employed to verify the effects of bee pollen on memory-related signaling molecules in the hippocampus. Bee pollen extract (100 or 300 mg/kg, per os (p.o.)) obviously reversed scopolamine-caused cognitive impairment in the passive avoidance test, ameliorated spontaneous alternation versus the scopolaminetreated group in the Y-maze test and prolonged swimming time in the target zone in the Morris water maze test. In addition, the phosphorylation levels of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB), protein kinase B (Akt) and glycogen synthase kinase-3β (GSK-3β), and the expression levels of brain-derived neurotrophic factor (BDNF) and tissue plasminogen activator (tPA) in the hippocampi, were increased in response to the treatment with bee pollen extract (100 or 300 mg/kg, p.o.). These results indicated that bee pollen ameliorates cognitive impairment induced by cholinergic blockade through the enhancing conversion of proBDNF to mature BDNF by tPA, probably, through the ERK-CREB pathway or Akt-GSK-3β signaling pathway and would be a useful agent for the treatment of cognitive dysfunction.

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Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study

Ren

Chen

Zhang

et al. 2020

J of Separation Science

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Oroxylin A, obtained from the root of Scutellaria baicalensis Georgi, is a flavonoid with antitumor and other pharmacological activities. Our previous studies showed for the first time that it is mainly metabolized to oroxylin A sodium sulfonate by sulfotransferase enzymes in beagle dogs. In this study, rapid, universal, selective, and robust ultra‐high‐performance liquid chromatography–tandem mass spectrometry methods were established and fully validated to quantitatively detect oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dog plasma. The quantitative analysis for oroxylin A sodium sulfonate was reported for the first time. Plasma samples were processed with acetonitrile, a universal protein precipitant. Gradient elution was performed to resolve carryover effects and to achieve separation efficiency and sufficient chromatographic retention. The linear relationships of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in plasma were in the range of 2.0–500.0, 5.0–500.0, and 1.881–940.5 ng/mL, respectively. The assay method was successfully applied to pharmacokinetic study. This is the first paper that reveals the pharmacokinetic profile of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate after single‐dose intravenous and oral administration of Oroxylin A in beagle dogs.

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Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice

Cited by 24 publications

References 56 publications

Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner

Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner

The Ameliorating Effects of Bee Pollen on Scopolamine-Induced Cognitive Impairment in Mice

Determination of oroxylin A, oroxylin A 7‐O‐glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study

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