Oroxylin A attenuates psoriasiform skin inflammation by direct targeting p62 (sequestosome 1) via suppressing M1 macrophage polarization
Yuxiang Ma,
Yunyao Liu,
You Zhong
et al.
Abstract:Background and PurposePsoriasis results from the interplay of innate and adaptive immunity in the skin. Oroxylin A (OA) has shown anti‐inflammatory effects in various disorders. This study explores oroxylin A potential in treating psoriasis, particularly its impact on type I macrophage (Mφ1) polarization.Experimental ApproachOroxylin A‐mediated therapeutic effects were evaluated using imiquimod‐induced or IL‐23‐injected psoriatic mice models, followed by proteomics assays to predict potential signalling and ta… Show more
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