Oropouche Virus Detection in Febrile Patients’ Saliva and Urine Samples in Salvador, Bahia, Brazil

Fonseca, Larissa Moraes dos Santos; Carvalho, Renata; Bandeira, António; Sardi, Silvia Inês; Campos, Gúbio Soares

doi:10.7883/yoken.jjid.2019.296

Cited by 11 publications

(9 citation statements)

References 13 publications

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“…On this basis, the use of urine samples to diagnose ZIKV, which represented the most appropriate individual test, is strongly advised. Such results are supported by recent studies in which similar recommendations were also made [ 4 , 9 , 17 , 21 , 22 , 23 , 34 , 35 , 36 ].…”

Section: Resultssupporting

confidence: 87%

Non-Invasive versus Invasive Samples for Zika Virus Surveillance: A Comparative Study in New Caledonia and French Guiana in 2015–2016

et al. 2021

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Zika virus, an arbovirus responsible for major outbreaks, can cause serious health issues, such as neurological diseases. In the present study, different types of samples (serum, saliva, and urine), collected in 2015–2016 in New Caledonia and French Guiana from 53 patients presenting symptoms and clinical signs triggered by arbovirus infections, were analyzed using a recently developed, and in-house validated, 4-plex RT-qPCR TaqMan method for simultaneous detection and discrimination of the Zika and Chikungunya viruses. Subsequently, statistical analyses were performed in order to potentially establish recommendations regarding the choice of samples type to use for an efficient and early stage Zika infection diagnosis. On this basis, the use of only urine samples presented the highest probability to detect viral RNA from Zika virus. Moreover, such a probability was improved using both urine and saliva samples. Consequently, the added value of non-invasive samples, associated with a higher acceptance level for collection among patients, instead of serum samples, for the detection of Zika infections was illustrated.

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Section: Resultssupporting

confidence: 87%

Non-Invasive versus Invasive Samples for Zika Virus Surveillance: A Comparative Study in New Caledonia and French Guiana in 2015–2016

et al. 2021

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“…OROV has also been increasingly reported in neurological disorder cases in Brazil [ 32 ]. These recent findings show that OROV has been silently circulating outside the Amazon region [ 66 , 67 , 68 ].…”

Section: Orthobunyaviruses In Brazilmentioning

confidence: 99%

“…Recent reports indicate that OROV circulates also in the west-central [ 30 , 66 ], northeast and southeast regions of the country. Autochthonous cases of oropouche fever, as well antibodies detection, were recently reported in Bahia state, which is of concern as the state located in northeast Brazil is famous for attracting hundreds of thousands of tourists from all over the world every year for Carnival celebrations [ 67 , 103 ].…”

Section: Serogroups Of Orthobunyaviruses In Brazilmentioning

confidence: 99%

An Overview of Neglected Orthobunyaviruses in Brazil

Dias

Santos

Pauvolid‐Corrêa

2022

Viruses

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Dozens of orthobunyaviruses have been isolated in Brazil, and at least thirteen have been associated with human disease. The Oropouche virus has received most attention for having caused explosive epidemics with hundreds of thousands of cases in the north region between the 1960sand the 1980s, and since then has been sporadically detected elsewhere in the country. Despite their importance, little is known about their enzootic cycles of transmission, amplifying hosts and vectors, and biotic and abiotic factors involved in spillover events to humans. This overview aims to combine available data of neglected orthobunyaviruses of several serogroups, namely, Anopheles A, Anopheles B, Bunyamwera, California, Capim, Gamboa, Group C, Guama, Simbu and Turlock, in order to evaluate the current knowledge and identify research gaps in their natural transmission cycles in Brazil to ultimately point to the future direction in which orthobunyavirus research should be guided.

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“…OROV screening was performed on samples from humans, nonhuman primates, arthropods, mammals, avian species, and reptiles. Of the 56 articles that were focused on the detection of OROV, there were 46 [4,15,24,44,47,51,76], and 3 diagnostic development studies [54,55,61].…”

Section: Orov Detectionmentioning

confidence: 99%

“…,15,34,47,49,53-55,60,61,66,72,73,76], or both (13 studies)[4,7,16,17,24,32,42,44,51,56,57,65,70]. Humans were tested for OROV antibodies (11 studies)[5,18,[38][39][40]58,63,64,68,69,78], OROV nucleic acid (19 of studies)[3,6,8,34,43,[47][48][49][53][54][55]59,61,62,66,72,73,76,77], or both (17 studies)[4,7,[15][16][17]24,32,41,…”

mentioning

confidence: 99%

Observational Characterization of the Ecological and Environmental Features Associated with the Presence of Oropouche Virus and the Primary Vector Culicoides paraensis: Data Synthesis and Systematic Review

2021

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Oropouche virus (OROV), a member of the Orthobunyavirus genus, is an arthropod-borne virus (arbovirus) and is the etiologic agent of human and animal disease. The primary vector of OROV is presumed to be the biting midge, Culicoides paraenesis, though Culex quinquefasciatus, Cq. venezuelensis, and Aedes serratus mosquitoes are considered secondary vectors. The objective of this systematic review is to characterize locations where OROV and/or its primary vector have been detected. Synthesis of known data through review of published literature regarding OROV and vectors was carried out through two independent searches: one search targeted to OROV, and another targeted towards the primary vector. A total of 911 records were returned, but only 90 (9.9%) articles satisfied all inclusion criteria. When locations were characterized, some common features were noted more frequently than others, though no one characteristic was significantly associated with presence of OROV using a logistic classification model. In a separate correlation analysis, vector presence was significantly correlated only with the presence of restingas. The lack of significant relationships is likely due to the paucity of data regarding OROV and its eco-epidemiology and highlights the importance of continued focus on characterizing this and other neglected tropical diseases.

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Oropouche Virus Detection in Febrile Patients’ Saliva and Urine Samples in Salvador, Bahia, Brazil

Cited by 11 publications

References 13 publications

Non-Invasive versus Invasive Samples for Zika Virus Surveillance: A Comparative Study in New Caledonia and French Guiana in 2015–2016

Non-Invasive versus Invasive Samples for Zika Virus Surveillance: A Comparative Study in New Caledonia and French Guiana in 2015–2016

An Overview of Neglected Orthobunyaviruses in Brazil

Observational Characterization of the Ecological and Environmental Features Associated with the Presence of Oropouche Virus and the Primary Vector Culicoides paraensis: Data Synthesis and Systematic Review

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