Oropouche infection a neglected arbovirus in patients with acute febrile illness from the Peruvian coast

Abstract

Objective: To evaluate the frequency of infection caused by the Oropouche virus (OROV) in 496 patients with acute febrile disease (AFI), whose samples were obtained for the analysis of endemic arboviruses in a previous investigation carried out in 2016. Results: OROV was detected in 26.4% (131/496) of serum samples from patients with AFI. Co-infections with Dengue virus (7.3%), Zika virus (1.8%) and Chikungunya (0.2%) were observed. The most common clinical symptoms reported among the patients with OROV infections were headache 85.5% (112/131), myalgia 80.9% (106/131), arthralgia 72.5% (95/131) and loss of appetite 67.9% (89/131). Headache and myalgia were predominant in all age groups. Both OROV infections and co-infections were more frequent in May, June and July corresponding to the dry season of the region.

Emergent Arboviruses: A Review About Mayaro virus and Oropouche orthobunyavirus

“…Other South American countries also faced the presence of OROV, such as Ecuador (Guayaquil) (10,75); Peru (Martin, Santa Clara, Cajamarca, Cusco, Yurimaguas, Madre de Dios, Iquitos -Loreto, Bagazan-Pachiza, Huańuco, Leoncio Prado, Puerto Maldonado (62,(76)(77)(78)(79), Panama (Chame/San Miguelito, Bejuco, Chilibre), Venezuela, Argentina and Bolivia (64,73,78,79). Given the current situation of OROV, it is possible to note the silent expansion of this virus.…”

“…In addition, it was not uncommon to find studies reporting the identification of OROV in patients with suspected other viral infections, as well as co-infections with DENV, ZIKV and CHIKV (77). Simultaneous co-infection with two or three different viruses alters the immune response but does not imply more clinical severe symptomatology than single viral infections (81).…”

Observational Characterization of the Ecological and Environmental Features Associated with the Presence of Oropouche Virus and the Primary Vector Culicoides paraensis: Data Synthesis and Systematic Review

“…Across all 56 articles included for OROV surveillance, there were eight separate countries where these investigations took place (Figure 3). There were 37 studies performed in Brazil (63%) [2,5,7,16,17,24,32,, followed by 11 studies in Peru (18.6%) [6,18,34,[68][69][70][71][72][73][74][75], with the remaining (18.6%) taking place in Ecuador [3,8,15,70,76], Paraguay [70,77], Suriname [78], Trinidad [4], Bolivia [70], and Costa Rica [79].…”

“…Before the emergence of Zika and chikungunya in the western hemisphere, OROV was recognized as being the second most common arboviral cause of human febrile illness in Brazil, second to dengue virus [33]. Though this virus is recognized as the etiologic agent of human disease and is known to infect animals, there is a scarcity in screening and detection outside of known areas associated with detected outbreaks [34][35][36]. Nevertheless, there is increased call for expanded screening of OROV across South America due to the significant number of cases and symptom similarity to other arboviruses to accurately attribute disease with specific pathogens [15,35].…”

“…,15,34,47,49,53-55,60,61,66,72,73,76], or both (13 studies)[4,7,16,17,24,32,42,44,51,56,57,65,70]. Humans were tested for OROV antibodies (11 studies)[5,18,[38][39][40]58,63,64,68,69,78], OROV nucleic acid (19 of studies)[3,6,8,34,43,[47][48][49][53][54][55]59,61,62,66,72,73,76,77], or both (17 studies)[4,7,[15][16][17]24,32,41,…”