Oropharyngeal squamous cell carcinoma incidence and mortality trends in the United States, 1973–2013

Megwalu, Uchechukwu C.; Sirjani, Davud; Devine, Erin E.

doi:10.1002/lary.26972

Cited by 19 publications

(20 citation statements)

References 22 publications

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“…Oropharyngeal carcinoma is an important cause of morbidity and mortality with rising incidence rates in recent years 1,2 . Five‐year overall survival is estimated to be 66.2% 3 .…”

Section: Introductionmentioning

confidence: 99%

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The role of insurance status as a mediator of racial disparities in oropharyngeal cancer outcomes

Shukla

Megwalu

2021

Head & Neck

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Background To assess the role of insurance status as a mediator of racial disparities in oropharyngeal cancer outcomes. Methods This was a population‐based retrospective cohort study. Data were extracted from the Surveillance, Epidemiology, and End Results 18 database. The study cohort included 11 627 patients diagnosed with oropharyngeal squamous cell carcinoma between 2010 and 2015. Results The association between black race and increased risk of unresectable disease was slightly attenuated, but persistent, after including insurance status as a covariate (odds ratio [OR] 1.34, 95%CI 1.10–1.63). Likewise, black race was no longer associated with worse disease‐specific survival (hazard ratio [HR] 1.11, 95%CI 0.99–1.26), but remained associated with worse overall survival with a slightly decreased effect size (HR 1.13, 95%CI 1.01–1.25). Conclusions Insurance status plays a significant role in, but does not completely account for, the persistent racial disparities in oropharyngeal cancer outcomes.

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“…Oropharyngeal carcinoma is an important cause of morbidity and mortality with rising incidence rates in recent years 1,2 . Five‐year overall survival is estimated to be 66.2% 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Oropharyngeal carcinoma is an important cause of morbidity and mortality with rising incidence rates in recent years. 1,2 Five-year overall survival is estimated to be 66.2%. 3 Histologically, squamous cell carcinoma makes up 90% of all oropharyngeal carcinoma cases.…”

Section: Introductionmentioning

confidence: 99%

The role of insurance status as a mediator of racial disparities in oropharyngeal cancer outcomes

Shukla

Megwalu

2021

Head & Neck

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“…Oropharyngeal cancer (OPC) represents a growing subset of head and neck cancer with over 90 000 new cases diagnosed and 51 000 deaths worldwide in 2018 1 . Whereas traditional risk factors include tobacco and alcohol use, human papillomavirus (HPV) has become a distinct cause of a number of oropharyngeal squamous cell carcinomas 2‐5 . Patients with HPV‐related OPC have improved survival compared to their HPV‐negative counterparts 3,6‐9 .…”

Section: Introductionmentioning

confidence: 99%

“…1 Whereas traditional risk factors include tobacco and alcohol use, human papillomavirus (HPV) has become a distinct cause of a number of oropharyngeal squamous cell carcinomas. [2][3][4][5] Patients with HPV-related OPC have improved survival compared to their HPV-negative counterparts. 3,[6][7][8][9] However, approximately one-third of patients with HPV-related OPC are considered high-risk, and many of these patients ultimately develop recurrence or metastases.…”

Section: Introductionmentioning

confidence: 99%

Aspirin use predicts prolonged survival in patients with oropharyngeal cancer: Nationwide Veterans Affairs database study

Clark

Newark

Fokar³

et al. 2020

Head & Neck

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Background: Single-institution studies suggest that aspirin reduces the risk of death in head and neck cancer. The aim of this study was to investigate the effect of aspirin use on overall survival (OS) in veterans with oropharyngeal cancer (OPC). Methods: A total of 23 083 veterans with OPC were identified between 2005 and 2018 from the Veterans Health Administration Corporate Data Warehouse. Records were queried for clinical-demographic data, aspirin prescriptions, and outcomes. Three-year OS was estimated. A Cox model was used to estimate hazard ratios (HR) for aspirin use. Results: Among the 23 083 identified veterans, 17 206 veterans met inclusion criteria. 21.8% used aspirin. Three-year OS was prolonged for aspirin users (66%) compared to nonaspirin users (54%; P < .001). Adjusted HR for death for nonaspirin users was 1.75 (95% confidence interval (CI) [1.60-1.91]). The average treatment effect of aspirin on survival using inverse probability weighting was 10% (95% CI [0.08-0.11]). Conclusion: Aspirin use following OPC diagnosis was independently associated with improved 3-year OS among veterans nationwide.

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“…Oropharyngeal cancer is strongly associated with environmental risk factors and lifestyles, as well as with sexually transmitted infection by human papillomavirus . While its incidence shows an increasing trend over the years, the survival rate appears to be improving . Traditional TNM staging has been found to have limited predictive utility to assess survival for this type of cancer .…”

Section: Introductionmentioning

confidence: 99%

A critical appraisal of the clinical applicability and risk of bias of the predictive models for mortality and recurrence in patients with oropharyngeal cancer: Systematic review

et al. 2019

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The use of predictive models is becoming widespread. However, these models should be developed appropriately (CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modeling Studies [CHARMS] and Prediction model Risk Of Bias ASsessment Tool [PROBAST] statements). Concerning mortality/recurrence in oropharyngeal cancer, we are not aware of any systematic reviews of the predictive models. We carried out a systematic review of the MEDLINE/EMBASE databases of those predictive models. In these models, we analyzed the 11 domains of the CHARMS statement and the risk of bias and applicability, using the PROBAST tool. Six papers were finally included in the systematic review and all of them presented high risk of bias and several limitations in the statistical analysis. The applicability was satisfactory in five out of six studies. None of the models could be considered ready for use in clinical practice.

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Oropharyngeal squamous cell carcinoma incidence and mortality trends in the United States, 1973–2013

Abstract: 2b. Laryngoscope, 128:1582-1588, 2018.

Cited by 19 publications

References 22 publications

The role of insurance status as a mediator of racial disparities in oropharyngeal cancer outcomes

The role of insurance status as a mediator of racial disparities in oropharyngeal cancer outcomes

Aspirin use predicts prolonged survival in patients with oropharyngeal cancer: Nationwide Veterans Affairs database study

A critical appraisal of the clinical applicability and risk of bias of the predictive models for mortality and recurrence in patients with oropharyngeal cancer: Systematic review

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