Oropharyngeal HPV Detection Techniques in HPV-associated Head and Neck Cancer Patients

Eggersmann, Tanja K.; Baumeister, Philipp; Kumbrink, Jörg; Mayr, Doris; Schmoeckel, Elisa; Thaler, Christian J.; Dannecker, Christian; Jeschke, Udo; Nagler, Thomas; Mahner, Sven; Sharaf, Kariem; Gallwas, Julia

doi:10.21873/anticanres.14170

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…In the equation, the variance of pixels in the window is σ 2, and C1 and C2 of Figure 1 represent the average gray value of pixels, namely, the dispersion of gray value of pixels in the image. The larger the SSIM value as the covariance of the image block x and y , the more similar the structural information between the noise removal image and the original image [ 24 , 25 ]. Figure 1 shows the image denoising process.…”

Section: Methodsmentioning

confidence: 99%

Ultrasonic Elastography Combined with Human Papilloma Virus Detection Based on Intelligent Denoising Algorithm in Diagnosis of Cervical Intraepithelial Neoplasia

Sun

Shan

Dong

et al. 2021

Computational and Mathematical Methods in Medicine

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The aim of this research was to study the application of ultrasonic elastography combined with human papilloma virus (HPV) detection based on bilateral filter intelligent denoising algorithm in the diagnosis of cervical intraepithelial neoplasia (CIN) and provide a theoretical basis for clinical diagnosis and treatment of CIN. In this study, 100 patients with cervical lesions were selected as research objects and randomly divided into control group and experimental group, with 50 cases in each group. Patients in control group and experimental group were diagnosed by ultrasonic elastography combined with HPV detection. The experimental group used the optimized image map of bilateral filter intelligent denoising algorithm for denoising and optimization, while the control group did not use optimization, and the differences between them were analyzed and compared. The diagnostic effects of the two groups were compared. As a result, the three accuracy rates of the experimental group were 95%, 95%, and 98%, respectively; the three sensitivity rates were 96%, 92%, and 94%, respectively; and the three specificity rates were 99%, 97%, and 98%, respectively. In the control group, the three accuracy rates were 84%, 86%, and 84%, respectively; the three sensitivity rates were 88%, 84%, and 86%, respectively; and the three specificity rates were 81%, 83%, and 88%, respectively. The accuracy, sensitivity, and specificity of experiment group were significantly higher than those of control group, and the difference was statistically significant ( P < 0.05 ). In summary, the bilateral filter intelligent denoising algorithm has a good denoising effect on the ultrasonic elastography. The ultrasonic image processed by the algorithm combined with HPV detection has a better diagnosis of CIN.

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Section: Methodsmentioning

confidence: 99%

Ultrasonic Elastography Combined with Human Papilloma Virus Detection Based on Intelligent Denoising Algorithm in Diagnosis of Cervical Intraepithelial Neoplasia

Sun

Shan

Dong

et al. 2021

Computational and Mathematical Methods in Medicine

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“…It is proven that the detection of HPV in patients with macroscopically visible tumors is more sensitive than in patients where the tumor is not visible. One study concludes that all “superficial” HPV detection methods are insufficient in collecting material when the tumor is not macroscopically visible [ 24 ]. This calls for further studies to establish the most precise method and to standardize sample collection in order to ensure equal and adequate HPV DNA extraction in future studies.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Prophylactic HPV Vaccines on Oral and Oropharyngeal HPV Infection—A Systematic Review

Nielsen

Jakobsen

Jensen

et al. 2021

Viruses

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Human papillomavirus (HPV) imposes an increased risk of developing cervical, anal and oropharyngeal cancer. In the Western world, HPV infection is currently the major cause of oropharyngeal cancer. The effectiveness of HPV vaccines for oral or oropharyngeal HPV infection is yet to be determined. This study conducted a systematic literature search in Pubmed and Embase. Studies investigating the impact of HPV vaccines on oral or oropharyngeal HPV infection were enrolled. This review reports the relative prevention percentage (RPP), including a risk of bias assessment as well as a quality assessment study. Nine studies were included (48,777 participants): five cross-sectional studies; one randomized community trial study (RCT); one longitudinal cohort study; and two case-control studies. A significant mean RPP of 83.9% (66.6–97.8%) was calculated from the cross-sectional studies, 82.4% in the included RCT and 83% in the longitudinal cohort study. Further, two case-control studies that measured antibody response in participants immunized with HPV vaccines were included. Respectively, 100% and 93.2% of participants developed HPV-16 Immunoglobulin G (IgG) antibodies in oral fluids post-vaccination. Analysis of the studies identified a significant decrease in vaccine-type oral or oropharyngeal HPV infections in study participants immunized with HPV vaccines across study designs and heterogenous populations. Further, a significant percentage of participants developed IgG antibodies in oral fluid post-vaccination.

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“…Bürstenzytologien der Gaumenmandeln und des Zungengrundes werden bei wachen Personen schlecht toleriert [87] und sind wegen des schlechten Zugangs zu den Tonsillenkrypten, in denen die Tumoren häufig entstehen, wenig sensitiv [88]. Mund-und Rachenspülproben werden in verschiedenen Studien zur Detektion von oralen HPV-Infektionen genutzt [75,89], zeigen aber selbst bei inzidenten HPV-positiven OPSCC-Patienten nur eine Sensitivität von ca.…”

Section: Früherkennung Durch Hpv-screeningunclassified

Update: Epidemiologie und Prävention des Oropharynxkarzinoms

Dietz,

Wichmann,

Wiegand

et al. 2024

Laryngorhinootologie

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Oropharyngeal HPV Detection Techniques in HPV-associated Head and Neck Cancer Patients

Cited by 9 publications

References 18 publications

Ultrasonic Elastography Combined with Human Papilloma Virus Detection Based on Intelligent Denoising Algorithm in Diagnosis of Cervical Intraepithelial Neoplasia

Ultrasonic Elastography Combined with Human Papilloma Virus Detection Based on Intelligent Denoising Algorithm in Diagnosis of Cervical Intraepithelial Neoplasia

The Effect of Prophylactic HPV Vaccines on Oral and Oropharyngeal HPV Infection—A Systematic Review

Update: Epidemiologie und Prävention des Oropharynxkarzinoms

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