Oropharyngeal dysphagia in a case of Huntington’s disease

Hamakawa, Sachiyo; Koda, Chieko; Umeno, Hirohito; Yoshida, Yoshikazu; Nakashima, Tadashi; Asaoka, Kyoko; Shoji, Hiroshi

doi:10.1016/j.anl.2003.11.001

Cited by 50 publications

(31 citation statements)

References 7 publications

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“…Five studies [13][14][15][16][17] directly linked to swallowing and dysphagia in HD were found (Appendix). Three studies were about dysphagia in HD [13][14][15], one case study was about laryngeal chorea in relation to swallowing [16], and one case study was about oropharyngeal dysphagia in HD, measuring the oral transit time, pharyngeal transit time, and esophageal response time [17].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies were about dysphagia in HD [13][14][15], one case study was about laryngeal chorea in relation to swallowing [16], and one case study was about oropharyngeal dysphagia in HD, measuring the oral transit time, pharyngeal transit time, and esophageal response time [17]. The studies used several objective methods and techniques.…”

Section: Resultsmentioning

confidence: 99%

“…Search terms included aerophagia, aspiration, asphyxiation, chest infection, choking, cineradiography, coughing, deglutition disorders, drinking, dysarthria, dysphagia, eating, drinking, fluoroscopy, food, ingestion, laryngeal chorea, mastication, penetration, phases of ingestion, pneumonia, swallowing, tongue, voice, and voice disorders in HD. The relevant studies [13][14][15][16][17] about dysphagia in HD were evaluated and summarized (Appendix). Studies were relevant if they were directly linked to swallowing, phases of ingestion, and dysphagia in HD; otherwise, they were excluded, such as studies about nutrition and dysarthria.…”

Section: Methodsmentioning

confidence: 99%

“…Death often results from aspiration pneumonia caused in turn by a progressive dysphagia [9][10][11][12]. Previous studies into dysphagia in HD investigated dysphagic features in the different phases of ingestion [13][14][15][16][17]. It is not known in what stage of HD the dysphagia becomes clinically apparent.…”

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confidence: 99%

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Dysphagia in Huntington’s Disease: A Review

2010

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Huntington's disease (HD) is a progressive neurodegenerative autosomal dominant disease characterized by disturbed movements and behavior and cognitive decline. The motor disturbances are both choreiform and hypokinetic. As a result of the combination of these signs, it is known that many patients with HD suffer from dysphagia. Little is known about the frequency and the characteristics of dysphagia in HD. Well-balanced strategies for treatment and prevention of dysphagia in HD are lacking. Therefore, we have performed a detailed survey of the literature. We found that the patient groups studied were heterogeneous and the methods used were highly variable, and no balanced advice for prevention and treatment was systematically proven.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Dysphagia in Huntington’s Disease: A Review

2010

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“…People with HD may experience changes in eating and swallowing patterns, which have a significant impact on the quality of life of patients and their family. These difficulties, known as dysphagia, seem to worsen as the disease progresses and cause life-threatening complications like aspiration pneumonia, malnutrition and dehydration [3][4][5][6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Dysphagia in Huntington's Disease: Correlation with Clinical Features

et al. 2015

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Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by motor impairment, cognitive decline and psychiatric disorders. Dysphagia is a pathologic condition that increases morbidity and mortality of the affected people. Our aim was to evaluate dysphagia in a group of HD patients in view of motor, cognitive and functional decline. Thirty-seven genetically confirmed HD patients were submitted to clinical evaluations of swallowing. Bedside Swallowing Assessment Scale (BSAS) was used. Dysphagia Outcome and Severity Scale (DOSS) was applied for a preliminary classification of swallowing difficulties. All patients were also evaluated by the Unified Huntington's Disease Rating Scale (UHDRS). A group of 39 controls comparable for sex and age were recruited for BSAS scores normalisation. The BSAS scores indicated that in our HD cohort, 32.4% presented relevant or severe dysphagia. The DOSS levels were significantly correlated with main clinical features, such as age, disease duration and motor impairment, with special regard to lingual protrusion ability, dysarthria and bradykinesia. The total functional capacity (TFC) and cognitive scales did not show significant correlation with DOSS levels. The results of clinical examination of swallowing indicated that dysphagia is a prevalent motor symptom of HD.

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Huntington Disease and Other Genetic Choreas

Jankovic

2011

Hyperkinetic Movement Disorders

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Oropharyngeal dysphagia in a case of Huntington’s disease

Cited by 50 publications

References 7 publications

Dysphagia in Huntington’s Disease: A Review

Dysphagia in Huntington’s Disease: A Review

Dysphagia in Huntington's Disease: Correlation with Clinical Features

Huntington Disease and Other Genetic Choreas

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