Oropharyngeal dysphagia and cachexia: Intertwined in head and neck cancer

Willemsen, Anna C.H.; Pilz, Walmari; Hoeben, Ann; Hoebers, Frank; Schols, A.M.W.J.; Baijens, Laura W. J.

doi:10.1002/hed.27288

Cited by 2 publications

(3 citation statements)

References 57 publications

(115 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high risk of sarcopenia based on these surrogate markers is an indication of sarcopenia treatment [15]. According to our knowledge, the study of Willemsen et al is the first to examine the relationship between cancer-related loss of skeletal muscle-and adipose tissue versus patient-reported OD in HNC patients prior to cancer treatment [69]. Both patient-reported OD using the EAT-10 and cancer-related loss of skeletal muscle mass and muscle function using, among others, the BMI, SPPB, and HGS were co-occurring conditions in HNC patients prior to cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Multi-Domain Screening: Identification of Patient’s Risk Profile Prior to Head-and-Neck Cancer Treatment

Wieland,

Pilz,

Winkens

et al. 2023

Cancers

Self Cite

View full text Add to dashboard Cite

Background: Head-and-neck cancer (HNC) can give rise to oropharyngeal dysphagia (OD), malnutrition, sarcopenia, and frailty. Early identification of these phenomena in newly diagnosed HNC patients is important to reduce the risk of complications and to improve treatment outcomes. The aim of this study was (1) to determine the prevalence of the risk of OD, malnutrition, sarcopenia, and frailty; and (2) to investigate the relation between these phenomena and patients’ age, performance status, and cancer group staging. Methods: Patients (N = 128) underwent multi-domain screening consisting of the Eating Assessment Tool-10 for OD, Short Nutritional Assessment Questionnaire and BMI for malnutrition, Short Physical Performance Battery and Hand Grip Strength for sarcopenia, and Distress Thermometer and Maastricht Frailty Screening Tool for frailty. Results: 26.2%, 31.0%, 73.0%, and 46.4% of the patients were at risk for OD, malnutrition, sarcopenia, or frailty, respectively. Patients with an advanced cancer stage had a significantly higher risk of OD and high levels of distress prior to cancer treatment. Conclusions: This study identified the risk profile of newly diagnosed HNC patients using a standardized ‘quick and easy’ multi-domain screening prior to cancer treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Multi-Domain Screening: Identification of Patient’s Risk Profile Prior to Head-and-Neck Cancer Treatment

Wieland,

Pilz,

Winkens

et al. 2023

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…While the negative impact of sarcopenia on HNC patient treatment tolerance and survival has become increasingly well‐documented, 6‐8 less is known about its associations with specific treatment‐related complications, such as dysphagia and aspiration. Patient‐reported dysphagia is a common complaint among HNC patients, with a reported incidence of 29% to 64% before oncologic treatment 9,10 . Sequelae of swallowing dysfunction resulting in aspiration can lead to pneumonia, malnutrition, dehydration, and death 11,12 …”

mentioning

confidence: 99%

“…Patient-reported dysphagia is a common complaint among HNC patients, with a reported incidence of 29% to 64% before oncologic treatment. 9,10 Sequelae of swallowing dysfunction resulting in aspiration can lead to pneumonia, malnutrition, dehydration, and death. 11,12 The association between sarcopenia and these complications, although not fully explained, could be due to the interplay of loss of muscle mass and degradation of function.…”

mentioning

confidence: 99%

Effect of Sarcopenia on Swallowing in Patients With Head and Neck Cancer

Colback,

Arkfeld,

Evangelista

et al. 2024

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectiveSarcopenia, characterized by decreased skeletal muscle mass, is associated with poorer oncologic outcomes in head and neck cancer (HNC) patients. The effect of sarcopenia on swallowing following HNC treatment is unknown. This study aims to investigate the association of sarcopenia and swallowing dysfunction in patients treated for HNC.Study DesignRetrospective cohort study.SettingAcademic medical center.MethodsPretreatment sarcopenia was assessed using the skeletal muscle index calculated from cross‐sectional imaging at the third cervical vertebra. Feeding tube dependence, patient‐reported dysphagia, and swallowing safety were assessed before and after treatment with the Functional Oral Intake Scale, Eating Assessment Tool‐10, and Penetration Aspiration Scale, respectively. The association between sarcopenia and swallowing dysfunction was evaluated.ResultsA total of 112 patients were included, 84 males (75%) and 28 females (25%). A total of 69 (61.6%) had sarcopenia prior to initiating HNC therapy. Sarcopenia was significantly associated with an elevated risk of patient‐reported dysphagia (odds ratio [OR] = 2.71 [95% confidence interval, CI, 1.12‐6.79]; P < .05). Multivariate logistic regression demonstrated that sarcopenia (OR = 15.18 [95% CI, 1.50‐453.53]; P < .05) is an independent predictor for aspiration following treatment for HNC.ConclusionPatients with pretreatment sarcopenia had higher rates of dysphagia before treatment and were more likely to develop aspiration after completion of HNC therapy. Sarcopenia is readily measured using cross‐sectional imaging and may be useful for identifying patients at risk of swallowing dysfunction and those most likely to benefit from prehabilitation efforts.

show abstract

Oropharyngeal dysphagia and cachexia: Intertwined in head and neck cancer

Cited by 2 publications

References 57 publications

Multi-Domain Screening: Identification of Patient’s Risk Profile Prior to Head-and-Neck Cancer Treatment

Multi-Domain Screening: Identification of Patient’s Risk Profile Prior to Head-and-Neck Cancer Treatment

Effect of Sarcopenia on Swallowing in Patients With Head and Neck Cancer

Contact Info

Product

Resources

About